{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:01:23Z","timestamp":1777795283322,"version":"3.51.4"},"reference-count":86,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    In vivo dopamine D2-receptor availability is frequently assessed with\n                    <jats:sup>11<\/jats:sup>\n                    C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for\n                    <jats:sup>11<\/jats:sup>\n                    C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal\n                    <jats:sup>11<\/jats:sup>\n                    C-raclopride binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test\u2013retest reliability in a sample of younger adults. The present work demonstrates high seven-month test\u2013retest reliability of striatal and extrastriatal\n                    <jats:sup>11<\/jats:sup>\n                    C-raclopride BP\n                    <jats:sub>ND<\/jats:sub>\n                    values in healthy, older adults (n\u2009=\u200927, age: 64\u201378 years). Mean\n                    <jats:sup>11<\/jats:sup>\n                    C-raclopride BP\n                    <jats:sub>ND<\/jats:sub>\n                    values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p\u2009&gt;\u20090.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85\u20130.96), absolute variability was low (mean: 4\u20138%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional\n                    <jats:sup>11<\/jats:sup>\n                    C-raclopride BP\n                    <jats:sub>ND<\/jats:sub>\n                    values correlated with previously determined\n                    <jats:sup>18<\/jats:sup>\n                    F-fallypride BP\n                    <jats:sub>ND<\/jats:sub>\n                    values (\u03c1\u2009=\u20090.97 and 0.92 in correlations with and without striatal values, respectively, p\u2009&lt;\u20090.01) and postmortem determined D2-receptor densities (including striatum: \u03c1\u2009=\u20090.92; p\u2009&lt;\u20090.001; excluding striatum: \u03c1\u2009=\u20090.75; p\u2009=\u20090.067). These observations suggest that extrastriatal\n                    <jats:sup>11<\/jats:sup>\n                    C-raclopride measurements represent a true D2 signal.\n                  <\/jats:p>","DOI":"10.1177\/0271678x19874770","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T21:58:35Z","timestamp":1568152715000},"page":"1859-1868","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["High long-term test\u2013retest reliability for extrastriatal\n                    <sup>11<\/sup>\n                    C-raclopride binding in healthy older adults"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-9453","authenticated-orcid":false,"given":"Nina","family":"Karalija","sequence":"first","affiliation":[{"name":"Department of Radiation Sciences, Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Ume\u00e5 Center for Functional Brain 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Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Salami","sequence":"additional","affiliation":[{"name":"Department of Radiation Sciences, Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Ume\u00e5 Center for Functional Brain Imaging (UFBI), Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Department of Integrative Medical Biology, Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden"},{"name":"Wallenberg Centre for Molecular Medicine, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micael","family":"Andersson","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Center for Functional Brain Imaging (UFBI), Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Department of Integrative Medical Biology, Ume\u00e5 University, Ume\u00e5, 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Mapping the landscape of human dopamine D2\/3 receptors with [(11)C]raclopride.\n                      Brain structure & function\n                      . Epub ahead of print 23 August 2019. 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