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The current study sought to determine changes in hippocampal oscillatory activity that may underlie the cognitive impairment observed following distal middle cerebral artery occlusion (dMCAO) without causing hippocampal structural damage. Local field potentials were recorded from the dorsal hippocampus and cortex in urethane-anesthetized rats with multichannel silicon probes during dMCAO and reperfusion, or mild ischemia induced by bilateral common carotid artery occlusion (CCAO). Bilateral change of brain state was evidenced by reduced theta\/delta amplitude ratio and shortened high theta duration following acute dMCAO but not CCAO. An aberrant increase in the occurrence of sharp-wave-associated ripples (150\u2013250\u2009Hz), crucial for memory consolidation, was only detected after dMCAO reperfusion, coinciding with an increased occurrence of high-frequency discharges (250\u2013450\u2009Hz). dMCAO also significantly affected the modulation of gamma amplitude in the cortex coupled to hippocampal theta phase, although both hippocampal theta and gamma power were temporarily decreased during dMCAO. Our results suggest that MCAO may disrupt the balance between excitatory and inhibitory circuits in the hippocampus and alter the function of cortico-hippocampal network, providing a novel insight in how cortical stroke affects function in remote brain regions.<\/jats:p>","DOI":"10.1177\/0271678x19877889","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T01:38:02Z","timestamp":1569548282000},"page":"1778-1796","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication"],"prefix":"10.1177","volume":"40","author":[{"given":"Ji-Wei","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, UCSF, San Francisco, CA, USA"},{"name":"Department of Neurological Surgery, SFVAMC, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gratianne","family":"Rabiller","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, UCSF, San Francisco, CA, USA"},{"name":"Department of Neurological Surgery, SFVAMC, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, UCSF, San Francisco, CA, USA"},{"name":"Department of Neurological Surgery, SFVAMC, San Francisco, CA, USA"},{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, UCSF, San Francisco, CA, USA"},{"name":"Department of Neurological Surgery, SFVAMC, San Francisco, CA, USA"},{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karam","family":"Khateeb","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Electrical and Computer Engineering, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Yazdan-Shahmorad","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Electrical and Computer Engineering, University of Washington, Seattle, WA, USA"},{"name":"Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, UCSF, San Francisco, CA, USA"},{"name":"Department of Neurological Surgery, SFVAMC, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"103","article-title":"Cognitive impairment after cerebrovascular stroke: relationship to vascular risk factors","volume":"5","author":"Khedr EM","year":"2009","unstructured":"Khedr EM, Hamed SA, El-Shereef HK, et al. 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