{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:01:47Z","timestamp":1777795307425,"version":"3.51.4"},"reference-count":59,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>The relationship between plaque morphology, cerebral micro-embolic signals (MES) and platelet biomarkers in carotid stenosis patients warrants investigation.<\/jats:p>\n                  <jats:p>We combined data from two prospective, observational studies to assess carotid plaque morphology and relationship with cerebral MES and platelet biomarkers in patients with recently symptomatic (\u22644 weeks of transient ischaemic attack (TIA)\/ischaemic stroke) versus asymptomatic carotid stenosis. Plaque morphology on ultrasound was graded with Grey-Scale Median (GSM) and Gray\u2013Weale (GW) scoring. Bilateral transcranial Doppler ultrasound classified patients as \u2018MES+ve\u2019 or \u2018MES-ve\u2019. Full blood counts were analysed and flow cytometry quantified CD62P and CD63 expression, leucocyte-platelet complexes and reticulated platelets.<\/jats:p>\n                  <jats:p>\n                    Data from 42 recently symptomatic carotid stenosis patients were compared with those from 36 asymptomatic patients. There were no differences in median GSM scores between symptomatic and asymptomatic patients (25 vs. 30; P\u2009=\u20090.31) or between MES+ve vs. MES-ve symptomatic patients (36 vs. 25; P\u2009=\u20090.09). Symptomatic patients with GSM-echodense plaques (GSM \u226525) had higher platelet counts (228 vs. 191\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L), neutrophil\u2013platelet (3.3 vs. 2.7%), monocyte\u2013platelet (6.3 vs. 4.55%) and lymphocyte\u2013platelet complexes (2.91 vs. 2.53%) than \u2018 asymptomatic patients with GSM-echodense plaques\u2019 ( P \u2264 0.03).\n                  <\/jats:p>\n                  <jats:p>Recently, symptomatic carotid stenosis patients with \u2018GSM-echodense plaques\u2019 have enhanced platelet production\/secretion\/activation compared with their asymptomatic counterparts. Simultaneous assessment with neurovascular imaging and platelet biomarkers may aid risk-stratification in carotid stenosis.<\/jats:p>","DOI":"10.1177\/0271678x19884427","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T01:22:47Z","timestamp":1573521767000},"page":"2201-2214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Simultaneous assessment of plaque morphology, cerebral micro-embolic signal status and platelet biomarkers in patients with recently symptomatic and asymptomatic carotid stenosis"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-2087","authenticated-orcid":false,"given":"Stephen J","family":"Murphy","sequence":"first","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon T","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin A","family":"Kinsella","sequence":"additional","affiliation":[{"name":"Department of Neurology, St Vincent's University Hospital, University College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-7214","authenticated-orcid":false,"given":"Sean","family":"Tierney","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim M","family":"Feeley","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Dublin Midlands Hospital Group, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Dooley","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinead M","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan","family":"Collins","sequence":"additional","affiliation":[{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Coughlan","sequence":"additional","affiliation":[{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Department of Medicine for the Elderly\/Stroke Service, St James's Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A","family":"Harbison","sequence":"additional","affiliation":[{"name":"Department of Medicine for the Elderly\/Stroke Service, St James's Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St James's Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean M","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St James's Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary P","family":"Colgan","sequence":"additional","affiliation":[{"name":"Centre for Advanced Medical Imaging, Department of Radiology, St James's Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim F","family":"Meaney","sequence":"additional","affiliation":[{"name":"Centre for Advanced Medical Imaging, Department of Radiology, St James's Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Department of Surgery, Royal Free Hampstead NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick JH","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, 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