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Here we imaged and quantified vessel length, tortuosity and width in 15 brain regions in young adult and aged mice. Our data indicate that vessel loss was most pronounced in white matter followed by cortical, then subcortical grey matter regions, while some regions (visual cortex, amygdala, thalamus) showed no decline with aging. Regions supplied by the anterior cerebral artery were more vulnerable to loss than those supplied by middle or posterior cerebral arteries. Vessel width and tortuosity generally increased with age but neither reliably predicted regional vessel loss. Since capillaries are naturally prone to plugging and prolonged obstructions often lead to vessel pruning, we hypothesized that regional susceptibilities to plugging could help predict vessel loss. By mapping the distribution of microsphere-induced capillary obstructions, we discovered that regions with a higher density of persistent obstructions were more likely to show vessel loss with aging and vice versa. These findings indicate that age-related vessel loss is region specific and can be explained, at least partially, by regional susceptibilities to capillary plugging.<\/jats:p>","DOI":"10.1177\/0271678x19895245","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T02:24:34Z","timestamp":1578277474000},"page":"2475-2490","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":70,"title":["Susceptibility to capillary plugging can predict brain region specific vessel loss with aging"],"prefix":"10.1177","volume":"40","author":[{"given":"Ben","family":"Schager","sequence":"first","affiliation":[{"name":"Division of Medical Sciences, University of Victoria, Victoria, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences, University of Victoria, Victoria, BC, Canada"},{"name":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,5]]},"reference":[{"key":"bibr1-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200110000-00001"},{"key":"bibr2-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.002"},{"key":"bibr3-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1085-05.2005"},{"key":"bibr4-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3287-09.2009"},{"key":"bibr5-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3426"},{"key":"bibr6-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16671146"},{"key":"bibr7-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20493"},{"key":"bibr8-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.008"},{"key":"bibr9-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0557-x"},{"key":"bibr10-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1038\/srep46427"},{"key":"bibr11-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.02.007"},{"key":"bibr12-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0329-4"},{"key":"bibr13-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(02)00064-8"},{"key":"bibr14-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.064"},{"key":"bibr15-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01139.x"},{"key":"bibr16-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0430"},{"key":"bibr17-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.14.2.224"},{"key":"bibr18-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi044"},{"key":"bibr19-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2012.00021"},{"key":"bibr20-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16655172"},{"key":"bibr21-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.011"},{"key":"bibr22-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12738"},{"key":"bibr23-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17743877"},{"key":"bibr24-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33670"},{"key":"bibr25-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10117"},{"key":"bibr26-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.01.006"},{"key":"bibr27-0271678X19895245","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx180"},{"key":"bibr28-0271678X19895245","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin K","year":"2008","edition":"3"},{"key":"bibr29-0271678X19895245","unstructured":"Schager B. 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