{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:54:48Z","timestamp":1792648488918,"version":"4.5.0"},"reference-count":88,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Mild traumatic brain injury (mTBI) is a risk factor for Alzheimer\u2019s disease (AD), and evidence suggests cerebrovascular dysregulation initiates deleterious neurodegenerative cascades. We examined whether mTBI history alters cerebral blood flow (CBF) and cortical thickness in regions vulnerable to early AD-related changes. Seventy-four young to middle-aged Veterans (mean age\u2009=\u200934, range\u2009=\u200923\u201348) underwent brain scans. Participants were divided into: (1) Veteran Controls ( n\u2009= \u200927), (2) 1\u20132 mTBIs ( n\u2009= \u200926), and (2) 3+ mTBIs ( n\u2009= \u200921) groups. Resting CBF was measured using MP-PCASL. T1 structural scans were processed with FreeSurfer. CBF and cortical thickness estimates were extracted from nine AD-vulnerable regions. Regression analyses examined whether mTBI moderated the association between age, CBF, and cortical thickness. Regressions adjusting for sex and posttraumatic stress revealed mTBI moderated the association between age and CBF of the precuneus as well as superior and inferior parietal cortices ( p\u2019s\u2009&lt;\u2009.05); increasing age was associated with lower CBF in the 3+ mTBIs group, but not in the VCs or 1\u20132 mTBIs groups. mTBI did not moderate associations between age and cortical thickness ( p\u2019s &gt;.05). Repetitive mTBI is associated with cerebrovascular dysfunction in AD-vulnerable regions and may accelerate pathological aging trajectories.<\/jats:p>","DOI":"10.1177\/0271678x19897443","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T06:59:06Z","timestamp":1587020346000},"page":"431-444","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Repetitive mTBI is associated with age-related reductions in cerebral blood flow but not cortical thickness"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-5409","authenticated-orcid":false,"given":"Alexandra L","family":"Clark","sequence":"first","affiliation":[{"name":"VA San Diego Healthcare System (VASDHS), San Diego, CA, USA"},{"name":"School of Medicine, Department of Psychiatry, University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J","family":"Weigand","sequence":"additional","affiliation":[{"name":"San Diego State University\/University of California, San Diego (SDSU\/UCSD) Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J","family":"Bangen","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System (VASDHS), San Diego, CA, USA"},{"name":"School of Medicine, Department of Psychiatry, University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C","family":"Merritt","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System (VASDHS), San Diego, CA, USA"},{"name":"School of Medicine, Department of Psychiatry, University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Bondi","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System (VASDHS), San Diego, CA, USA"},{"name":"School of Medicine, Department of Psychiatry, University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Delano-Wood","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System (VASDHS), San Diego, CA, USA"},{"name":"School of Medicine, Department of Psychiatry, University of California San Diego, San Diego, CA, USA"},{"name":"Center of Excellence for Stress and Mental Health, VASDHS, San Diego, CA, 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