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Certain microbiomes, especially those related to inflammation, appear to closely reflect the homeostasis and dysbiosis of both the brain and the gut, suggesting their potential application as biomarkers and therapeutic targets. A paradigm shift from purely central towards incorporating peripheral sequestration of cell death pathways may improve stroke therapeutic outcomes. Recognizing this gut-brain axis as key to disease pathology and treatment is likely to usher innovative approaches in cell-based regenerative medicine for stroke.<\/jats:p>","DOI":"10.1177\/0271678x19900037","type":"journal-article","created":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T23:41:00Z","timestamp":1581896460000},"page":"1132-1134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["A gut feeling about stroke reveals gut-brain axis\u2019 active role in homeostasis and dysbiosis"],"prefix":"10.1177","volume":"40","author":[{"given":"Brooke","family":"Bonsack","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rays HY","family":"Jiang","sequence":"additional","affiliation":[{"name":"Global and Planetary Health, College of Public Health, University of South Florida USF Genomics Program, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar V","family":"Borlongan","sequence":"additional","affiliation":[{"name":"Global and Planetary Health, College of Public Health, University of South Florida USF Genomics Program, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,16]]},"reference":[{"key":"bibr1-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18782789"},{"key":"bibr2-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18780130"},{"key":"bibr3-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16661201"},{"key":"bibr4-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17697988"},{"key":"bibr5-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17708917"},{"key":"bibr6-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18773871"},{"key":"bibr7-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2018.06.004"},{"key":"bibr8-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1038\/srep34400"},{"key":"bibr9-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14429"},{"key":"bibr10-0271678X19900037","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-019-09906-2"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X19900037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X19900037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X19900037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:44Z","timestamp":1777493564000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X19900037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,16]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1177\/0271678X19900037"],"URL":"https:\/\/doi.org\/10.1177\/0271678x19900037","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,16]]}}}