{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:00:34Z","timestamp":1787756434357,"version":"build-2784847793"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>\n                    We tested the hypothesis that increasing the nitric oxide (NO) bioavailability by dietary nitrate would recover the hypoxia-induced reduction in dynamic cerebral autoregulation (CA). Twelve healthy males (age 21\u2009\u00b1\u20092\u2009years) completed four days of dietary supplementation with a placebo or inorganic nitrate drink (140-ml beetroot juice per day) followed by 60-min of normoxia or hypoxia (fraction of inspired oxygen [FiO\n                    <jats:sub>2<\/jats:sub>\n                    ]\u2009=\u200913%). Duplex ultrasonography was used to perform volumetric change-based assessment of dynamic CA in the internal carotid artery (ICA). Dynamic CA was assessed by rate of regulation (RoR) of vascular conductance using the thigh-cuff method. Four days of beetroot supplementation increased circulating nitrate by 208 [171,245] \u03bcM (mean difference [95% confidence interval]) compared with placebo. Dynamic CA was lower in hypoxia than normoxia (RoR \u0394\u22120.085 [\u22120.116, \u22120.054]). Compared with placebo, nitrate did not alter dynamic CA in normoxia (RoR \u0394\u22120.022 [\u22120.060, 0.016]) or hypoxia (RoR \u03940.017 [\u22120.019, 0.053]). Further, nitrate did not affect ICA vessel diameter, blood velocity or flow in either normoxia or hypoxia. Increased bioavailability of NO through dietary nitrate supplementation did not recover the hypoxia-induced reduction in dynamic CA. This suggests the mechanism of hypoxia-induced reduction in dynamic CA does not relate to the availability of NO.\n                  <\/jats:p>","DOI":"10.1177\/0271678x20910053","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T01:40:02Z","timestamp":1583804402000},"page":"486-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Dietary nitrate supplementation effect on dynamic cerebral autoregulation in normoxia and acute hypoxia"],"prefix":"10.1177","volume":"42","author":[{"given":"Masahiro","family":"Horiuchi","sequence":"first","affiliation":[{"name":"Division of Human Environmental Science, Mt. Fuji Research Institute, Fujiyoshida, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9610-6066","authenticated-orcid":false,"given":"Gabriella MK","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Extremes Research Group, College of Human Sciences, Bangor University, Bangor, Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-9546","authenticated-orcid":false,"given":"Samuel J","family":"Oliver","sequence":"additional","affiliation":[{"name":"Extremes Research Group, College of Human Sciences, Bangor University, Bangor, Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"bibr1-0271678X20910053","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2667-y"},{"key":"bibr2-0271678X20910053","first-page":"161","volume":"2","author":"Paulson 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