{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:41:45Z","timestamp":1777794105304,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>\n                    RNA-binding protein fox-1 homolog 1 (Rbfox-1), an RNA-binding protein in neurons, is thought to be associated with many neurological diseases. To date, the mechanism on which Rbfox-1 worsens secondary cell death in ICH remains poorly understood. In this study, we aimed to explore the role of Rbfox-1 in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) and to identify its underlying mechanisms. We found that the expression of Rbfox-1 in neurons was significantly increased after ICH, which was accompanied by increases in the binding of Rbfox-1 to Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/calmodulin-dependent protein kinase II (CaMKII\u03b1) mRNA and the protein level of CaMKII\u03b1. In addition, when exposed to exogenous upregulation or downregulation of Rbfox-1, the protein level of CaMKII\u03b1 showed a concomitant trend in brain tissue, which further suggested that CaMKII\u03b1 is a downstream-target protein of Rbfox-1. The upregulation of both proteins caused intracellular-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    overload and neuronal degeneration, which exacerbated brain damage. Furthermore, we found that Rbfox-1 promoted the expression of CaMKII\u03b1 via blocking the binding of micro-RNA-124 to CaMKII\u03b1 mRNA. Thus, Rbfox-1 is expected to be a promising therapeutic target for SBI after ICH.\n                  <\/jats:p>","DOI":"10.1177\/0271678x20916860","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:27:58Z","timestamp":1587342478000},"page":"530-545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Rbfox-1 contributes to CaMKII\u03b1 expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124"],"prefix":"10.1177","volume":"41","author":[{"given":"Fang","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"School of Nursing, Medical College of Soochow University, Suzhou, 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