{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:11:07Z","timestamp":1790709067611,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    Mitochondrial complex I (MC-I) is an essential regulator of brain bioenergetics and can be quantified in the brain using PET radioligand\n                    <jats:sup>18<\/jats:sup>\n                    F-BCPP-EF. Here we evaluate the test\u2013retest reproducibility of\n                    <jats:sup>18<\/jats:sup>\n                    F-BCPP-EF in humans, and assess the use of a non-invasive quantification method (standardised uptake value ratio \u2013 SUVR). Thirty healthy volunteers had a 90-min dynamic\n                    <jats:sup>18<\/jats:sup>\n                    F-BCPP-EF scan with arterial blood sampling, five of which received a second scan to be included in the test\u2013retest analysis. Time-activity curves (TAC) were analysed using multilinear analysis 1 (MA1) and the two-tissue compartment model (2TC) to estimate volumes of distribution (V\n                    <jats:sub>T<\/jats:sub>\n                    ). Regional SUVR-1 values were calculated from the 70 to 90-min TAC data using the centrum semiovale as a pseudo reference region, and compared to kinetic analysis-derived outcome measures. The mean absolute test\u2013retest variability of V\n                    <jats:sub>T<\/jats:sub>\n                    ranged from 12% to 18% across regions. Both DVR-1and SUVR-1 had improved test\u2013retest variability in the range 2%\u20137%. SUVR-1 was highly correlated with DVR-1 (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.97, n\u2009=\u200930). In conclusion,\n                    <jats:sup>18<\/jats:sup>\n                    F-BCPP-EF has suitable test\u2013retest reproducibility and can be used to quantify MC-I in clinical studies.\n                  <\/jats:p>","DOI":"10.1177\/0271678x20928149","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T09:05:02Z","timestamp":1591347902000},"page":"771-779","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Test\u2013retest variability and reference region-based quantification of\n                    <sup>18<\/sup>\n                    F-BCPP-EF for imaging mitochondrial complex I in the human brain"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-5745","authenticated-orcid":false,"given":"Ayla","family":"Mansur","sequence":"first","affiliation":[{"name":"Invicro LLC, Boston, MA, USA"},{"name":"Division of Brain Sciences, Imperial College London, UK"},{"name":"MIND MAPS Consortium, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenii A","family":"Rabiner","sequence":"additional","affiliation":[{"name":"Invicro LLC, Boston, MA, USA"},{"name":"MIND MAPS Consortium, London, UK"},{"name":"Institute of Psychiatry, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Tsukada","sequence":"additional","affiliation":[{"name":"MIND MAPS Consortium, London, UK"},{"name":"Hamamatsu Photonics, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Comley","sequence":"additional","affiliation":[{"name":"MIND MAPS Consortium, London, UK"},{"name":"Abbvie, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Lewis","sequence":"additional","affiliation":[{"name":"Invicro LLC, Boston, MA, USA"},{"name":"MIND MAPS Consortium, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Huiban","sequence":"additional","affiliation":[{"name":"Invicro LLC, Boston, MA, USA"},{"name":"MIND MAPS Consortium, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Passchier","sequence":"additional","affiliation":[{"name":"Invicro LLC, Boston, MA, USA"},{"name":"Division of Brain Sciences, Imperial College London, UK"},{"name":"MIND MAPS Consortium, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger N","family":"Gunn","sequence":"additional","affiliation":[{"name":"Invicro LLC, Boston, MA, USA"},{"name":"Division of Brain Sciences, Imperial College London, UK"},{"name":"MIND MAPS Consortium, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"bibr1-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3997"},{"key":"bibr2-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4400"},{"key":"bibr3-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14037"},{"key":"bibr4-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3056"},{"key":"bibr5-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2628-z"},{"key":"bibr6-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.5"},{"key":"bibr7-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.169615"},{"key":"bibr8-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.228080"},{"key":"bibr9-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3430-11.2012"},{"key":"bibr10-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17708691"},{"issue":"2","key":"bibr11-0271678X20928149","first-page":"58","volume":"9","author":"Grabner G","year":"2006","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"bibr12-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.044"},{"key":"bibr13-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"bibr14-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf6667"},{"key":"bibr15-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.17"},{"key":"bibr16-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.190"},{"key":"bibr17-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.038"},{"key":"bibr18-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.11.020"},{"key":"bibr19-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu040"},{"key":"bibr20-0271678X20928149","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17725418"}],"container-title":["Journal of Cerebral Blood Flow &amp; 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