{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:50:48Z","timestamp":1791906648431,"version":"4.3.4"},"reference-count":67,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Due to the use of improvised explosive devices, blast exposure and mild traumatic brain injury (mTBI) have become hallmark injuries of the Iraq and Afghanistan wars. Although the mechanisms of the effects of blast on human neurobiology remain active areas of investigation, research suggests that the cerebrovasculature may be particularly vulnerable to blast via molecular processes that impact cerebral blood flow. Given that recent work suggests that blast exposure, even without a subsequent TBI, may have negative consequences on brain structure and function, the current study sought to further understand the effects of blast exposure on perfusion. One hundred and eighty military personnel underwent pseudo-continuous arterial spin labeling (pCASL) imaging and completed diagnostic and clinical interviews. Whole-brain analyses revealed that with an increasing number of total blast exposures, there was significantly increased perfusion in the right middle\/superior frontal gyri, supramarginal gyrus, lateral occipital cortex, and posterior cingulate cortex as well as bilateral anterior cingulate cortex, insulae, middle\/superior temporal gyri and occipital poles. Examination of other neurotrauma and clinical variables such as close-range blast exposures, mTBI, and PTSD yielded no significant effects. These results raise the possibility that perfusion may be an important neural marker of brain health in blast exposure.<\/jats:p>","DOI":"10.1177\/0271678x20935190","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T02:12:46Z","timestamp":1593051166000},"page":"886-900","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Cerebral perfusion is associated with blast exposure in military personnel without moderate or severe TBI"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-5887","authenticated-orcid":false,"given":"Danielle R","family":"Sullivan","sequence":"first","affiliation":[{"name":"National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Miller","sequence":"additional","affiliation":[{"name":"National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika J","family":"Wolf","sequence":"additional","affiliation":[{"name":"National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Logue","sequence":"additional","affiliation":[{"name":"National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E","family":"Robinson","sequence":"additional","affiliation":[{"name":"Core for Advanced MRI and Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B","family":"Fortier","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R","family":"Fonda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA"},{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny JJ","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, USA"},{"name":"Department of Neurology, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P","family":"Milberg","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina E","family":"McGlinchey","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Salat","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA"},{"name":"Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA"},{"name":"Athinoula A. 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