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Here we studied the burden of age-related CAA pathology on WM disease in a novel transgenic rat model of CAA type 1 (rTg-DI). A cohort of rTg-DI and wild-type rats was scanned longitudinally using MRI for characterization of morphometry, cerebral microbleeds (CMB) and WM integrity. In rTg-DI rats, a distinct pattern of WM loss was observed at 9\u2009M and 11\u2009M. MRI also revealed manifestation of small CMB in thalamus at 6\u2009M, which preceded WM loss and progressively enlarged until the moribund disease stage. Histology revealed myelin loss in the corpus callosum and thalamic CMB in all rTg-DI rats, the latter of which manifested in close proximity to occluded and calcified microvessels. The quantitation of CAA load in rTg-DI rats revealed that the most extensive microvascular A\u03b2 deposition occurred in the thalamus. For the first time using in vivo MRI, we show that CAA type 1 pathology alone is associated with a distinct pattern of WM loss.<\/jats:p>","DOI":"10.1177\/0271678x20944226","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T10:06:32Z","timestamp":1597399592000},"page":"1103-1118","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy"],"prefix":"10.1177","volume":"41","author":[{"given":"Hedok","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"George and Anne Ryan Institute for Neuroscience and the Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, RI, 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