{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T01:48:24Z","timestamp":1784339304651,"version":"3.55.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n                    Diffusion-time- ( t\n                    <jats:sub>d<\/jats:sub>\n                    ) dependent diffusion MRI (dMRI) extends our ability to characterize brain microstructure by measuring dMRI signals at varying t\n                    <jats:sub>d<\/jats:sub>\n                    . The use of oscillating gradient (OG) is essential for accessing short t\n                    <jats:sub>d<\/jats:sub>\n                    but is technically challenging on clinical MRI systems. This study aims to investigate the clinical feasibility and value of t\n                    <jats:sub>d<\/jats:sub>\n                    -dependent dMRI in neonatal hypoxic-ischemic encephalopathy (HIE). Eighteen HIE neonates and six normal term-born neonates were scanned on a 3\u2009T scanner, with OG-dMRI at an oscillating frequency of 33\u2009Hz (equivalent t\n                    <jats:sub>d<\/jats:sub>\n                    \u2009\u2248\u20097.5\u2009ms) and pulsed gradient (PG)-dMRI at a t\n                    <jats:sub>d<\/jats:sub>\n                    of 82.8\u2009ms and b-value of 700\u2009s\/mm\n                    <jats:sup>2<\/jats:sup>\n                    . The t\n                    <jats:sub>d<\/jats:sub>\n                    -dependence, as quantified by the difference in apparent diffusivity coefficients between OG- and PG-dMRI (\u0394ADC), was observed in the normal neonatal brains, and the \u0394ADC was higher in the subcortical white matter than the deep grey matter. In HIE neonates with severe and moderate injury, \u0394ADC significantly increased in the basal ganglia (BG) compared to the controls (23.7% and 10.6%, respectively). In contrast, the conventional PG-ADC showed a 12.6% reduction only in the severe HIE group. White matter edema regions also demonstrated increased \u0394ADC, where PG-ADC did not show apparent changes. Our result demonstrated that t\n                    <jats:sub>d<\/jats:sub>\n                    -dependent dMRI provided high sensitivity in detecting moderate-to-severe HIE.\n                  <\/jats:p>","DOI":"10.1177\/0271678x20944353","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T01:06:05Z","timestamp":1597799165000},"page":"1240-1250","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Feasibility of oscillating and pulsed gradient diffusion MRI to assess neonatal hypoxia-ischemia on clinical systems"],"prefix":"10.1177","volume":"41","author":[{"given":"Fusheng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruicheng","family":"Ba","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"bibr1-0271678X20944353","volume-title":"Neurology of the newborn","author":"Volpe 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