{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:22:54Z","timestamp":1780597374420,"version":"3.54.1"},"reference-count":84,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n                    Huntington\u2019s disease (HD) is a neurodegenerative disease caused by a CAG triplet repeat expansion in the Huntingtin gene. Metabolic and microvascular abnormalities in the brain may contribute to early physiological changes that subserve the functional impairments in HD. This study is intended to investigate potential abnormality in dynamic changes in cerebral blood volume (CBV) and cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ) in the brain in response to functional stimulation in premanifest and early manifest HD patients. A recently developed 3-D-TRiple-acquisition-after-Inversion-Preparation magnetic resonance imaging (MRI) approach was used to measure dynamic responses in CBV, CBF, and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    during visual stimulation in one single MRI scan. Experiments were conducted in 23 HD patients and 16 healthy controls. Decreased occipital cortex CMRO\n                    <jats:sub>2<\/jats:sub>\n                    responses were observed in premanifest and early manifest HD patients compared to controls ( P\u2009&lt;\u20090.001), correlating with the CAG-Age Product scores in these patients ( R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.4, P\u2009=\u20090.001). The results suggest the potential value of this reduced CMRO\n                    <jats:sub>2<\/jats:sub>\n                    response during visual stimulation as a biomarker for HD and may illuminate the role of metabolic alterations in the pathophysiology of HD.\n                  <\/jats:p>","DOI":"10.1177\/0271678x20949286","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:55:04Z","timestamp":1597712104000},"page":"1119-1130","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington\u2019s disease"],"prefix":"10.1177","volume":"41","author":[{"given":"Peter","family":"Klinkmueller","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA"},{"name":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kronenbuerger","sequence":"additional","affiliation":[{"name":"Division of Movement Disorders, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Neurology, University of Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Miao","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee","family":"Bang","sequence":"additional","affiliation":[{"name":"Division of Movement Disorders, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kia E","family":"Ultz","sequence":"additional","affiliation":[{"name":"Division of Movement Disorders, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Paez","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhen","family":"Duan","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Departments of Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell L","family":"Margolis","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter CM van","family":"Zijl","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Ross","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Departments of Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hua","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"bibr1-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"bibr2-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30992"},{"key":"bibr3-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.24"},{"key":"bibr4-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.208264"},{"key":"bibr5-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"bibr6-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"bibr7-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70263-0"},{"key":"bibr8-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.04.003"},{"key":"bibr9-0271678X20949286","first-page":"215","volume":"47","author":"Ciarmiello A","year":"2006","journal-title":"J Nucl Med"},{"key":"bibr10-0271678X20949286","first-page":"1591","volume":"42","author":"Feigin A","year":"2001","journal-title":"J Nucl Med"},{"key":"bibr11-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080118"},{"key":"bibr12-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110612"},{"key":"bibr13-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.6.2085"},{"key":"bibr14-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609833104"},{"key":"bibr15-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69411"},{"key":"bibr16-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25009"},{"key":"bibr17-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6099-5"},{"key":"bibr18-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25010"},{"key":"bibr19-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.157"},{"key":"bibr20-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.104"},{"key":"bibr21-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04323.x"},{"key":"bibr22-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.12.2689"},{"key":"bibr23-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.1033"},{"key":"bibr24-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.018"},{"key":"bibr25-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.09.013"},{"key":"bibr26-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.07.010"},{"key":"bibr27-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.06.008"},{"key":"bibr28-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.10.016"},{"key":"bibr29-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45691"},{"key":"bibr30-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.112"},{"key":"bibr31-0271678X20949286","first-page":"773","volume":"41","author":"Deckel AW","year":"2000","journal-title":"J Nucl Med"},{"key":"bibr32-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.9.1667"},{"key":"bibr33-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.11.1018"},{"key":"bibr34-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-007-0085-4"},{"key":"bibr35-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.60"},{"key":"bibr36-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1576"},{"key":"bibr37-0271678X20949286","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02506-3"},{"key":"bibr38-0271678X20949286","unstructured":"Lin C-Y, Huang C-H, Lin M-H, et\u00a0al. 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