{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:35:15Z","timestamp":1792510515541,"version":"4.5.0"},"reference-count":112,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Previous studies have investigated whether migraine is a circulatory disorder, as migraineurs are at heightened risk of cerebrovascular disease. However, in most cases, systemic vascular function was evaluated, which may not reflect abnormalities in the cerebral circulation. Therefore, we aimed to determine whether cerebrovascular function differs between migraineurs and controls. A systematic literature search was conducted across three electronic databases to search for studies that compared cerebrovascular function in migraineurs to controls. Where applicable, meta-analyses were used to determine standardised mean differences (SMD) between migraineurs and controls. Seventy articles were identified, 40 of which contained quantitative data. Meta-analyses showed pulsatility index (PI) was higher (SMD\u2009=\u20090.23; 95%CI\u2009=\u20090.05 to 0.42, P\u2009=\u20090.01) and cerebrovascular responsiveness (CVR) to hypercapnia was lower (SMD=\u22120.34; 95%CI=\u22120.67 to \u22120.01, P\u2009=\u20090.04) in the posterior circulation of migraineurs, particularly those without aura. The meta-analyses also indicated that migraineurs have higher resting mean blood flow velocity in both anterior (SMD\u2009=\u20090.14; 95%CI\u2009=\u20090.05 to 0.23, P\u2009=\u20090.003) and posterior circulations (SMD\u2009=\u20090.20; 95%CI\u2009=\u20090.05 to 0.34, P\u2009=\u20090.007). Compared to healthy controls, migraineurs have altered cerebrovascular function, evidenced by elevated PI (representing arterial stiffness) and impaired CVR to hypercapnia (representing cerebral vasodilator function). Future studies should investigate whether improvement of cerebrovascular function is able to alleviate migraine.<\/jats:p>","DOI":"10.1177\/0271678x20964344","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T03:07:59Z","timestamp":1603336079000},"page":"919-944","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Profiling cerebrovascular function in migraine: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"41","author":[{"given":"Jemima SA","family":"Dzator","sequence":"first","affiliation":[{"name":"Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter RC","family":"Howe","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia"},{"name":"Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Springfield Central, Queensland, Australia"},{"name":"UniSA Allied Health & Human Performance, University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel HX","family":"Wong","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia"},{"name":"Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Springfield Central, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"bibr1-0271678X20964344","unstructured":"Organisation WH. Headache disorders, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/headache-disorders (2016, accessed 1 September 2020)."},{"key":"bibr2-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.11.071"},{"key":"bibr3-0271678X20964344","unstructured":"Victoria So. Headache \u2013 migraine, https:\/\/www.betterhealth.vic.gov.au\/health\/ConditionsAndTreatments\/headache-migraine (2018, accessed 1 September 2020)"},{"key":"bibr4-0271678X20964344","unstructured":"Medicine USNLo. Migraine, https:\/\/medlineplus.gov\/migraine.html (2018, accessed 1 September 2020)"},{"key":"bibr5-0271678X20964344","unstructured":"Society IH. 1.3 Chronic migraine, 2019."},{"key":"bibr6-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199902000-00001"},{"key":"bibr7-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.182302"},{"key":"bibr8-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7502"},{"key":"bibr9-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-80"},{"key":"bibr10-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1080\/10623320701346692"},{"key":"bibr11-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-146"},{"key":"bibr12-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309571"},{"key":"bibr13-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116887"},{"key":"bibr14-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"bibr15-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"bibr16-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.2298\/VSP160421338P"},{"key":"bibr17-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S144183"},{"key":"bibr18-0271678X20964344","volume":"18","author":"Choi HA","year":"2017","journal-title":"J Headache Pain"},{"key":"bibr19-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-014-0375-y"},{"key":"bibr20-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414554661"},{"key":"bibr21-0271678X20964344","first-page":"704","volume":"24","author":"Karadas O","year":"2014","journal-title":"Turk Neurosurg"},{"key":"bibr22-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1754-0"},{"key":"bibr23-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.644674"},{"key":"bibr24-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01468.x"},{"key":"bibr25-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.02.020"},{"key":"bibr26-0271678X20964344","first-page":"655","volume":"47","author":"El-Khawas HM","year":"2010","journal-title":"Egypt J Neurol Psychiatr Neurosurg"},{"key":"bibr27-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-0879-2"},{"key":"bibr28-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20350"},{"key":"bibr29-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00740.x"},{"key":"bibr30-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03091.x"},{"key":"bibr31-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03009.x"},{"key":"bibr32-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00365.x"},{"key":"bibr33-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.041007704.x"},{"key":"bibr34-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1999.019005492.x"},{"key":"bibr35-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1998.3808608.x"},{"key":"bibr36-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1998.1803133.x"},{"key":"bibr37-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1703191.x"},{"key":"bibr38-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1996.3601037.x"},{"key":"bibr39-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1995.1505399.x"},{"key":"bibr40-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb01033.x"},{"key":"bibr41-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1994.hed3404198.x"},{"key":"bibr42-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1306395.x"},{"key":"bibr43-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1993.hed3308417.x"},{"key":"bibr44-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/jon199332109"},{"key":"bibr45-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1992.hed3209446.x"},{"key":"bibr46-0271678X20964344","first-page":"620","volume":"104","author":"Haring HP","year":"1992","journal-title":"Wien Klin Wochen"},{"key":"bibr47-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00918.x"},{"key":"bibr48-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01579.x"},{"key":"bibr49-0271678X20964344","first-page":"141","volume":"43","author":"Benedittis D","year":"1999","journal-title":"J Neurosurg Sci"},{"key":"bibr50-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3354-x"},{"key":"bibr51-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220637"},{"key":"bibr52-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418806861"},{"key":"bibr53-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415607857"},{"key":"bibr54-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319705"},{"key":"bibr55-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1998.1806353.x"},{"key":"bibr56-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.01.039"},{"key":"bibr57-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04006.x"},{"key":"bibr58-0271678X20964344","doi-asserted-by":"crossref","first-page":"10","DOI":"10.48208\/HeadacheMed.2011.3","volume":"2","author":"Sousa A","year":"2011","journal-title":"Headache Med"},{"key":"bibr59-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1990.1002095.x"},{"key":"bibr60-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1996.3605323.x"},{"key":"bibr61-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.3.5.566"},{"key":"bibr62-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1995.015003211.x"},{"key":"bibr63-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1991.hed3109593.x"},{"key":"bibr64-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04017.x"},{"key":"bibr65-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00219.x"},{"key":"bibr66-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/BF00867591"},{"key":"bibr67-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01843.x"},{"key":"bibr68-0271678X20964344","first-page":"II65","volume":"77","author":"Zaletel M","year":"2008","journal-title":"Zdravniski Vestnik Slovenian Med J"},{"key":"bibr69-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000177886.94134.92"},{"key":"bibr70-0271678X20964344","first-page":"223","volume":"26","author":"Wallasch TM","year":"2011","journal-title":"Funct Neurol"},{"key":"bibr71-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412474503"},{"key":"bibr72-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137971"},{"key":"bibr73-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.09.022"},{"key":"bibr74-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414552531"},{"key":"bibr75-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416649760"},{"key":"bibr76-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411435985"},{"key":"bibr77-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00625.x"},{"key":"bibr78-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0866-y"},{"key":"bibr79-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.02.016"},{"key":"bibr80-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01986.x"},{"key":"bibr81-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1998.1804202.x"},{"key":"bibr82-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1603161.x"},{"key":"bibr83-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1987.0704245.x"},{"key":"bibr84-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182a75927"},{"key":"bibr85-0271678X20964344","first-page":"190","volume":"98","author":"Mirza M","year":"1998","journal-title":"Acta Neurol Belg"},{"key":"bibr86-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3351-0"},{"key":"bibr87-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001625"},{"key":"bibr88-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.609057"},{"key":"bibr89-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002465"},{"key":"bibr90-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020498"},{"key":"bibr91-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.12.021"},{"key":"bibr92-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-014-0524-1"},{"key":"bibr93-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24441"},{"key":"bibr94-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071007"},{"key":"bibr95-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01389.x"},{"key":"bibr96-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.059"},{"key":"bibr97-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1111\/head.12304"},{"key":"bibr98-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-014-1471-y"},{"key":"bibr99-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0815-1"},{"key":"bibr100-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1730816"},{"key":"bibr101-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(93)90034-5"},{"key":"bibr102-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.02.014"},{"key":"bibr103-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.120022"},{"key":"bibr104-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057854"},{"key":"bibr105-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.559989"},{"key":"bibr106-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/sup026"},{"key":"bibr107-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002033"},{"key":"bibr108-0271678X20964344","first-page":"268483","volume":"2012","author":"Leoni RF","year":"2012","journal-title":"Radiol Res Pract"},{"key":"bibr109-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199607000-00027"},{"key":"bibr110-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0424-y"},{"key":"bibr111-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00633.2007"},{"key":"bibr112-0271678X20964344","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6157982"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X20964344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X20964344","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X20964344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:13:09Z","timestamp":1777493589000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X20964344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":112,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/0271678X20964344"],"URL":"https:\/\/doi.org\/10.1177\/0271678x20964344","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]}}}