{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:17:11Z","timestamp":1790421431019,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>\n                    Perinatal hypoxic ischemic encephalopathy (HIE) results in serious neurological dysfunction and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) have commenced in stroke using intravenous delivery of donor-derived Muse cells. Here, we investigated the therapeutic effects of human Muse cells in an HIE model. Seven-day-old rats underwent ligation of the left carotid artery then were exposed to 8% oxygen for 60\u2009min, and 72\u2009hours later intravenously transplanted with 1\u2009\u00d7\u200910\n                    <jats:sup>4<\/jats:sup>\n                    of human-Muse and -non-Muse cells, collected from bone marrow-mesenchymal stem cells as stage-specific embryonic antigen-3 (SSEA-3)+ and \u2212, respectively, or saline (vehicle) without immunosuppression. Human-specific probe revealed Muse cells distributed mainly to the injured brain at 2 and 4\u2009weeks, and expressed neuronal and glial markers until 6\u2009months. In contrast, non-Muse cells lodged in the lung at 2\u2009weeks, but undetectable by 4\u2009weeks. Magnetic resonance spectroscopy and positron emission tomography demonstrated that Muse cells dampened excitotoxic brain glutamatergic metabolites and suppressed microglial activation. Muse cell-treated group exhibited significant improvements in motor and cognitive functions at 4\u2009weeks and 5\u2009months. Intravenously transplanted Muse cells afforded functional benefits in experimental HIE possibly via regulation of glutamate metabolism and reduction of microglial activation.\n                  <\/jats:p>","DOI":"10.1177\/0271678x20972656","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T19:00:25Z","timestamp":1606071625000},"page":"1707-1720","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-1404","authenticated-orcid":false,"given":"Toshihiko","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan"},{"name":"Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kushida","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1540-3641","authenticated-orcid":false,"given":"Masahiro","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Wakao","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Ueda","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan"},{"name":"Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Iitani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9066-3489","authenticated-orcid":false,"given":"Shinobu","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-4508","authenticated-orcid":false,"given":"Hideki","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and Brain Sciences, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Temma","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Imaging, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Imaging, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Imaging, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Dezawa","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-9782","authenticated-orcid":false,"given":"Cesar V","family":"Borlongan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,22]]},"reference":[{"key":"bibr1-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12233"},{"key":"bibr2-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23647"},{"key":"bibr3-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18814614"},{"key":"bibr4-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"bibr5-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18811277"},{"key":"bibr6-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108317299"},{"key":"bibr7-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.2174\/157488809789057419"},{"key":"bibr8-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1159\/000368396"},{"key":"bibr9-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1038\/srep44111"},{"key":"bibr10-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00757"},{"key":"bibr11-0271678X20972656","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2016.0365"},{"key":"bibr12-0271678X20972656","doi-asserted-by":"crossref","unstructured":"Xin 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MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke\n                      . J Cereb Blood Flow Metab\n                      . Epub ahead of print 18 August 2020. 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Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: the role of Miro1.\n                      J Cereb Blood Flow Metab\n                      . Epub ahead of print 5 June 2020. 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