{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:11:31Z","timestamp":1793945491752,"version":"4.8.0"},"reference-count":70,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    Preclinical and postmortem studies have suggested that regional synaptic density and glucose consumption (CMRGlc) are strongly related. However, the relation between synaptic density and cerebral glucose metabolism in the human brain has not directly been assessed in vivo. Using [\n                    <jats:sup>11<\/jats:sup>\n                    C]UCB-J binding to synaptic vesicle glycoprotein 2\u2009A (SV2A) as indicator for synaptic density and [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG for measuring cerebral glucose consumption, we studied twenty healthy female subjects (age 29.6\u2009\u00b1\u20099.9 yrs) who underwent a single-day dual-tracer protocol (GE Signa PET-MR). Global measures of absolute and relative CMRGlc and specific binding of [\n                    <jats:sup>11<\/jats:sup>\n                    C]UCB-J were indeed highly significantly correlated ( r\u2009&gt;\u20090.47, p\u2009&lt;\u20090.001). However, regional differences in relative [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG and [\n                    <jats:sup>11<\/jats:sup>\n                    C]UCB-J uptake were observed, with up to 19% higher [\n                    <jats:sup>11<\/jats:sup>\n                    C]UCB-J uptake in the medial temporal lobe (MTL) and up to 17% higher glucose metabolism in frontal and motor-related areas and thalamus. This pattern has a considerable overlap with the brain regions showing different levels of aerobic glycolysis. Regionally varying energy demands of inhibitory and excitatory synapses at rest may also contribute to this difference. Being unaffected by astroglial and\/or microglial energy demands, changes in synaptic density in the MTL may therefore be more sensitive to early detection of pathological conditions compared to changes in glucose metabolism.\n                  <\/jats:p>","DOI":"10.1177\/0271678x20981502","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T22:29:03Z","timestamp":1610663343000},"page":"1978-1987","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-0144","authenticated-orcid":false,"given":"June","family":"van Aalst","sequence":"first","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ceccarini","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-4680","authenticated-orcid":false,"given":"Stefan","family":"Sunaert","sequence":"additional","affiliation":[{"name":"Translational MRI, Department of Imaging and Pathology, Leuven, Belgium"},{"name":"Radiology, UZ Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dupont","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Koole","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"},{"name":"Nuclear Medicine, UZ Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"bibr1-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02945-0"},{"key":"bibr2-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1126\/science.2860723"},{"key":"bibr3-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10625"},{"key":"bibr4-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.149"},{"key":"bibr5-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17708691"},{"key":"bibr6-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4492"},{"key":"bibr7-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200110000-00001"},{"key":"bibr8-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033425"},{"key":"bibr9-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00148"},{"key":"bibr10-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.168179"},{"key":"bibr11-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf6667"},{"key":"bibr12-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.36"},{"key":"bibr13-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.12.044"},{"key":"bibr14-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17724947"},{"key":"bibr15-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009818"},{"key":"bibr16-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1836"},{"key":"bibr17-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14122-0"},{"key":"bibr18-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09562-7"},{"key":"bibr19-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.02.003"},{"key":"bibr20-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12097"},{"key":"bibr21-0271678X20981502","first-page":"594","volume":"45","author":"Silverman DHS.","year":"2004","journal-title":"J Nucl Med"},{"key":"bibr22-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.002"},{"key":"bibr23-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.128.3.280"},{"key":"bibr24-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"bibr25-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4119-8"},{"key":"bibr26-0271678X20981502","doi-asserted-by":"crossref","DOI":"10.3389\/fphy.2019.00211","volume":"7","author":"Schramm G","year":"2019","journal-title":"Front Phys"},{"key":"bibr27-0271678X20981502","first-page":"950","volume":"37","author":"Hunter GJ","year":"1996","journal-title":"J Nucl Med"},{"key":"bibr28-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.220871"},{"key":"bibr29-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-019-01387-6"},{"key":"bibr30-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-1632(02)00122-1"},{"key":"bibr31-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"bibr32-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-1788-0_14"},{"key":"bibr33-0271678X20981502","doi-asserted-by":"crossref","unstructured":"Paulson OB, Hasselbalch SG, Rostrup E, et\u00a0al.\n                      J Cereb Blood Flow Metab\n                      2010; 30: 2\u201314.","DOI":"10.1038\/jcbfm.2009.188"},{"key":"bibr34-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022534709672"},{"key":"bibr35-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010459107"},{"key":"bibr36-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117003"},{"key":"bibr37-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08546-x"},{"key":"bibr38-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21974"},{"key":"bibr39-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4513"},{"key":"bibr40-0271678X20981502","doi-asserted-by":"crossref","unstructured":"Palomero-Gallagher N, Zilles K.\n                      Cyto- and receptor architectonic mapping of the human brain\n                      . 1st ed. Amsterdam: Elsevier B.V., 2018, pp. 355-387.","DOI":"10.1016\/B978-0-444-63639-3.00024-4"},{"key":"bibr41-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1758-13.2013"},{"key":"bibr42-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.012"},{"key":"bibr43-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.167858"},{"key":"bibr44-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"bibr45-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2005.09.007"},{"key":"bibr46-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3790-5"},{"key":"bibr47-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2955-8"},{"key":"bibr48-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.1"},{"key":"bibr49-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03525.x"},{"key":"bibr50-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.228"},{"key":"bibr51-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0723-9"},{"key":"bibr52-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19879230"},{"key":"bibr53-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1890.sp000321"},{"key":"bibr54-0271678X20981502","doi-asserted-by":"crossref","unstructured":"Madsen K, Hesby S, Poulsen I, et\u00a0al. Comparison of analytical methods of brain [18 F]FDG-PET after severe traumatic brain injury.\n                      J Neurosci Methods\n                      2017; 291: 176-181.","DOI":"10.1016\/j.jneumeth.2017.07.032"},{"key":"bibr55-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00156-3"},{"key":"bibr56-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04694-1"},{"key":"bibr57-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.02.011"},{"key":"bibr58-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19874643"},{"key":"bibr59-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.166439"},{"key":"bibr60-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29937-y"},{"key":"bibr61-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.11.027"},{"key":"bibr62-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0318"},{"key":"bibr63-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.1_Part_1.192"},{"key":"bibr64-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00222-6"},{"key":"bibr65-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00050-1"},{"key":"bibr66-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90349-4"},{"key":"bibr67-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009781"},{"key":"bibr68-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23659"},{"key":"bibr69-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.12.014"},{"key":"bibr70-0271678X20981502","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.10.009"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X20981502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X20981502","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X20981502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:13:14Z","timestamp":1777493594000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X20981502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1177\/0271678X20981502"],"URL":"https:\/\/doi.org\/10.1177\/0271678x20981502","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]}}}