{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:27:41Z","timestamp":1780590461074,"version":"3.54.1"},"reference-count":76,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Previous studies reported abnormally increased and\/or decreased blood oxygen level-dependent (BOLD) activations during functional tasks in subjective cognitive decline (SCD). The neurophysiological basis underlying these functional aberrations remains debated. This study aims to investigate vascular and metabolic responses and their dependence on cognitive processing loads during functional tasks in SCD. Twenty-one SCD and 18 control subjects performed parametric N-back working-memory tasks during MRI scans. Task-evoked percentage changes (denoted as \u03b4) in cerebral blood volume (\u03b4CBV), cerebral blood flow (\u03b4CBF), BOLD signal (\u03b4BOLD) and cerebral metabolic rate of oxygen (\u03b4CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ) were evaluated. In the frontal lobe, trends of decreased \u03b4CBV, \u03b4CBF and \u03b4CMRO\n                    <jats:sub>2<\/jats:sub>\n                    and increased \u03b4BOLD were observed in SCD compared with control subjects under lower loads, and these trends increased to significant differences under the 3-back load. \u03b4CBF was significantly correlated with \u03b4CMRO\n                    <jats:sub>2<\/jats:sub>\n                    in controls, but not in SCD subjects. As N-back loads increased, the differences between SCD and control subjects in \u03b4CBF and \u03b4CMRO\n                    <jats:sub>2<\/jats:sub>\n                    tended to enlarge. In the parietal lobe, no significant between-group difference was observed. Our findings suggested that impaired vascular and metabolic responses to functional tasks occurred in the frontal lobe of SCD, which contributed to unusual BOLD hyperactivation and was modulated by cognitive processing loads.\n                  <\/jats:p>","DOI":"10.1177\/0271678x211012153","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T03:00:51Z","timestamp":1620529251000},"page":"2743-2755","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Impaired cerebral vascular and metabolic responses to parametric N-back tasks in subjective cognitive decline"],"prefix":"10.1177","volume":"41","author":[{"given":"Yaoyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjie","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Dalian University of Technology, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Excellence in Brain Science and Intelligence Technology (Institute of Neuroscience), Chinese Academy of Sciences, Shanghai, 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City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China"},{"name":"McGovern Institute for Brain Research, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"bibr1-0271678X211012153","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30368-0"},{"key":"bibr2-0271678X211012153","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"bibr3-0271678X211012153","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.30"},{"key":"bibr4-0271678X211012153","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005863"},{"key":"bibr5-0271678X211012153","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12336"},{"key":"bibr6-0271678X211012153","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-020-00591-9","volume":"12","author":"Viviano 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