{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:43:51Z","timestamp":1790401431084,"version":"4.1.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>\n                    The novel tau-PET tracer [\n                    <jats:sup>18<\/jats:sup>\n                    F]PI-2620 detects the 3\/4-repeat-(R)-tauopathy Alzheimer\u2019s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [\n                    <jats:sup>18<\/jats:sup>\n                    F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3\/4R- and 4R-tauopathies. Ten patients with a 3\/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [\n                    <jats:sup>18<\/jats:sup>\n                    F]PI-2620 PET scans were acquired 0-60\u2009min p.i. and the distribution volume ratio (DVR) was calculated. [\n                    <jats:sup>18<\/jats:sup>\n                    F]PI-2620-positive clusters (DVR \u2265 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 &amp; k2a (efflux), DVR, 30-60\u2009min standardized-uptake-value-ratios (SUVR\n                    <jats:sub>30-60<\/jats:sub>\n                    ) and the linear slope of post-perfusion phase SUVR (9-60\u2009min p.i.) were compared between 3\/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1\n                    <jats:sub>SRTM<\/jats:sub>\n                    : 0.92\u2009\u00b1\u20090.21 vs. 0.83\u2009\u00b1\u20090.10, p\u2009=\u20090.0007), higher efflux (k2\n                    <jats:sub>SRTM<\/jats:sub>\n                    : 0.17\/min \u00b10.21\/min vs. 0.06\/min\u2009\u00b1\u20090.07\/min, p\u2009&lt;\u20090.0001), lower DVR (1.1\u2009\u00b1\u20090.1 vs. 1.4\u2009\u00b1\u20090.2, p\u2009&lt;\u20090.0001), lower SUVR\n                    <jats:sub>30-60<\/jats:sub>\n                    (1.3\u2009\u00b1\u20090.2 vs. 1.8\u2009\u00b1\u20090.3, p\u2009&lt;\u20090.0001) and flatter slopes of the post-perfusion phase (slope\n                    <jats:sub>9-60<\/jats:sub>\n                    : 0.006\/min\u2009\u00b1\u20090.007\/min vs. 0.016\/min\u2009\u00b1\u20090.008\/min, p\u2009&lt;\u20090.0001) when compared to 3\/4R-tau cases. [\n                    <jats:sup>18<\/jats:sup>\n                    F]PI-2620 binding characteristics in cortical regions differentiate 3\/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3\/4R-tauopathies.\n                  <\/jats:p>","DOI":"10.1177\/0271678x211018904","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T16:07:03Z","timestamp":1622304423000},"page":"2957-2972","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Binding characteristics of [\n                    <sup>18<\/sup>\n                    F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET"],"prefix":"10.1177","volume":"41","author":[{"given":"Mengmeng","family":"Song","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henryk","family":"Barthel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"van Eimeren","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany"},{"name":"Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany"},{"name":"Department of Neurology, University Hospital Cologne, Cologne, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Marek","sequence":"additional","affiliation":[{"name":"InviCRO, LLC, Boston, MA, USA"},{"name":"Molecular Neuroimaging, A Division of inviCRO, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nitschmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Scheifele","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Palleis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Respondek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Biechele","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Hammes","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e8rard","family":"Bischof","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Barbe","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Onur","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"},{"name":"Department of Psychiatry, University Hospital Cologne, Cologne, Germany"},{"name":"Center for Memory Disorders, University 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