{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:35:13Z","timestamp":1784748913413,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Selective therapeutic hypothermia (TH) showed promising preclinical results as a neuroprotective strategy in acute ischemic stroke. We aimed to assess safety and feasibility of an intracarotid cooling catheter conceived for fast and selective brain cooling during endovascular thrombectomy in an ovine stroke model.<\/jats:p>\n                  <jats:p>Transient middle cerebral artery occlusion (MCAO, 3\u2009h) was performed in 20 sheep. In the hypothermia group (n\u2009=\u200910), selective TH was initiated 20\u2009minutes before recanalization, and was maintained for another 3\u2009h. In the normothermia control group (n\u2009=\u200910), a standard 8 French catheter was used instead. Primary endpoints were intranasal cooling performance (feasibility) plus vessel patency assessed by digital subtraction angiography and carotid artery wall integrity (histopathology, both safety). Secondary endpoints were neurological outcome and infarct volumes.<\/jats:p>\n                  <jats:p>Computed tomography perfusion demonstrated MCA territory hypoperfusion during MCAO in both groups. Intranasal temperature decreased by 1.1\u2009\u00b0C\/3.1\u2009\u00b0C after 10\/60\u2009minutes in the TH group and 0.3\u2009\u00b0C\/0.4\u2009\u00b0C in the normothermia group (p\u2009&lt;\u20090.001). Carotid artery and branching vessel patency as well as carotid wall integrity was indifferent between groups. Infarct volumes (p\u2009=\u20090.74) and neurological outcome (p\u2009=\u20090.82) were similar in both groups.<\/jats:p>\n                  <jats:p>Selective TH was feasible and safe. However, a larger number of subjects might be required to demonstrate efficacy.<\/jats:p>","DOI":"10.1177\/0271678x211024952","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T06:47:34Z","timestamp":1624430854000},"page":"3097-3110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model"],"prefix":"10.1177","volume":"41","author":[{"given":"Giorgio FM","family":"Cattaneo","sequence":"first","affiliation":[{"name":"Institute for Biomedical Engineering, University of Stuttgart, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Institute of Veterinary Anatomy, Histology and Embryology, Leipzig University, Leipzig, Germany"},{"name":"Department of Neuroradiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian A","family":"Eiden","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Wieser","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Kellner","sequence":"additional","affiliation":[{"name":"Department of MR Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Doostkam","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"S\u00fc\u00df","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Fauth","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-0797","authenticated-orcid":false,"given":"Christoph J","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology, Universit\u00e4tsklinikum Augsburg, Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wolfertz","sequence":"additional","affiliation":[{"name":"Acandis GmbH, Pforzheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Nitzsche","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Institute of Veterinary Anatomy, Histology and Embryology, Leipzig University, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00fcchert","sequence":"additional","affiliation":[{"name":"Acandis GmbH, Pforzheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Jost","sequence":"additional","affiliation":[{"name":"Acandis GmbH, Pforzheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ihorst","sequence":"additional","affiliation":[{"name":"Department of Clinical Trials, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Haberstroh","sequence":"additional","affiliation":[{"name":"Center for Experimental Models and Transgenic Service (CEMT), Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"M\u00fclling","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Institute of Veterinary Anatomy, Histology and Embryology, Leipzig University, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Strecker","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Dirk","family":"Niesen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesch J","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, 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