{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:17:55Z","timestamp":1793319475179,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>We determined the occurrence and association of cortical cerebral microinfarcts (CMIs) at 7\u2009T MRI with risk factors, neuroimaging markers of small and large vessel disease, and cognitive functioning. Within the Medea-7T study, a diverse cohort of older persons with normal cognition, patients with vascular disease, and memory clinic patients, we included 386 participants (68\u2009\u00b1\u20099\u2009years) with available 7\u2009T and 1.5\u2009T\/3T brain MRI, and risk factor and neuropsychological data. CMIs were found in 10% of participants and were associated with older age (RR\u2009=\u20091.79 per +10\u2009years, 95%CI 1.28\u20132.50), history of stroke or TIA (RR\u2009=\u20094.03, 95%CI 2.18\u20137.43), cortical infarcts (RR\u2009=\u20095.28, 95%CI 2.91\u20139.55), lacunes (RR\u2009=\u20095.66, 95%CI 2.85\u201311.27), cerebellar infarcts (RR\u2009=\u20092.73, 95%CI 1.27\u20135.84) and decreased cerebral blood flow (RR\u2009=\u20091.35 per \u2212100\u2009ml\/min, 95%CI 1.00\u20131.83), after adjustment for age and sex. Furthermore, participants with &gt;2 CMIs had 0.5 SD (95%CI 0.05\u20130.91) lower global cognitive performance, compared to participants without CMIs. Our results indicate that CMIs on 7\u2009T MRI are observed in vascular and memory clinic patients with similar frequency, and are associated with older age, history of stroke or TIA, other brain infarcts, and poorer global cognitive functioning.<\/jats:p>","DOI":"10.1177\/0271678x211025447","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T03:44:40Z","timestamp":1625024680000},"page":"3127-3138","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning \u2013 The Medea-7T study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5779-3150","authenticated-orcid":false,"given":"Maarten HT","family":"Zwartbol","sequence":"first","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-0437","authenticated-orcid":false,"given":"Ina","family":"Rissanen","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-5276","authenticated-orcid":false,"given":"Rashid","family":"Ghaznawi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"de Bresser","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo J","family":"Kuijf","sequence":"additional","affiliation":[{"name":"Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Blom","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo D","family":"Witkamp","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiberdina 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