{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:45:44Z","timestamp":1777794344725,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:00:00Z","timestamp":1625961600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n                    Quantitative [\n                    <jats:sup>15<\/jats:sup>\n                    O]H\n                    <jats:sub>2<\/jats:sub>\n                    O positron emission tomography (PET) is the accepted reference method for regional cerebral blood flow (rCBF) quantification. To perform reliable quantitative [\n                    <jats:sup>15<\/jats:sup>\n                    O]H\n                    <jats:sub>2<\/jats:sub>\n                    O-PET studies in PET\/MRI scanners, MRI-based attenuation-correction (MRAC) is required. Our aim was to compare two MRAC methods (RESOLUTE and DeepUTE) based on ultrashort echo-time with computed tomography-based reference standard AC (CTAC) in dynamic and static [\n                    <jats:sup>15<\/jats:sup>\n                    O]H\n                    <jats:sub>2<\/jats:sub>\n                    O-PET. We compared rCBF from quantitative perfusion maps and activity concentration distribution from static images between AC methods in 25 resting [\n                    <jats:sup>15<\/jats:sup>\n                    O]H\n                    <jats:sub>2<\/jats:sub>\n                    O-PET scans from 14 healthy men at whole-brain, regions of interest and voxel-wise levels. Average whole-brain CBF was 39.9\u2009\u00b1\u20096.0, 39.0\u2009\u00b1\u20095.8 and 40.0\u2009\u00b1\u20095.6\u2009ml\/100\u2009g\/min for CTAC, RESOLUTE and DeepUTE corrected studies respectively. RESOLUTE underestimated whole-brain CBF by 2.1\u2009\u00b1\u20091.50% and rCBF in all regions of interest (range \u22122.4%\u2013 \u22121%) compared to CTAC. DeepUTE showed significant rCBF overestimation only in the occipital lobe (0.6\u2009\u00b1\u20091.1%). Both MRAC methods showed excellent correlation on rCBF and activity concentration with CTAC, with slopes of linear regression lines between 0.97 and 1.01 and R\n                    <jats:sup>2<\/jats:sup>\n                    over 0.99. In conclusion, RESOLUTE and DeepUTE provide AC information comparable to CTAC in dynamic [\n                    <jats:sup>15<\/jats:sup>\n                    O]H\n                    <jats:sub>2<\/jats:sub>\n                    O-PET but RESOLUTE is associated with a small but systematic underestimation.\n                  <\/jats:p>","DOI":"10.1177\/0271678x211029178","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T02:00:00Z","timestamp":1626055200000},"page":"3314-3323","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Deep-learning-based attenuation correction in dynamic [\n                    <sup>15<\/sup>\n                    O]H\n                    <sub>2<\/sub>\n                    O studies using PET\/MRI in healthy volunteers"],"prefix":"10.1177","volume":"41","author":[{"given":"Oriol","family":"Puig","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto M","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming L","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-6354","authenticated-orcid":false,"given":"Ulrich","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liselotte","family":"H\u00f8jgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes N","family":"Ladefoged","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,11]]},"reference":[{"key":"bibr1-0271678X211029178","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.09.043"},{"key":"bibr2-0271678X211029178","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1610"},{"key":"bibr3-0271678X211029178","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1291"},{"key":"bibr4-0271678X211029178","first-page":"782","volume":"24","author":"Herscovitch P","year":"1983","journal-title":"J Nucl Med"},{"key":"bibr5-0271678X211029178","first-page":"291","volume":"44","author":"Zaidi H","year":"2003","journal-title":"J Nucl Med"},{"key":"bibr6-0271678X211029178","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2003.127307"},{"key":"bibr7-0271678X211029178","author":"Puig O","journal-title":"J Cereb blood flow 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