{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:46:16Z","timestamp":1777794376519,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Physiological effects of spreading depolarizations (SD) are only well studied in the first hours after experimental stroke. In patients with malignant hemispheric stroke (MHS), monitoring of SDs is restricted to the postoperative ICU stay, typically day 2-7 post-ictus. Therefore, we investigated the role of physiological variables (temperature, intracranial pressure, mean arterial pressure and cerebral perfusion pressure) in relationship to SD during the late phase after MHS in humans. Additionally, an experimental stroke model was used to investigate hemodynamic consequences of SD during this time window. In 60 patients with MHS, the occurrence of 1692 SDs was preceded by a decrease in mean arterial pressure (\u22121.04\u2009mmHg; p\u2009=\u2009.02) and cerebral perfusion pressure (\u22121.04\u2009mmHg; p\u2009=\u2009.03). Twenty-four hours after middle cerebral artery occlusion in 50 C57Bl6\/J mice, hypothermia led to prolonged SD-induced hyperperfusion (+2.8\u2009min; p\u2009&lt;\u2009.05) whereas hypertension mitigated initial hypoperfusion (\u22121.4\u2009min and +18.5%\u0394 rCBF; p\u2009&lt;\u2009.01). MRI revealed that SDs elicited 24\u2009hours after experimental stroke were associated with lesion progression (15.9 vs. 14.8\u2009mm\u00b3; p\u2009&lt;\u2009.01). These findings of small but significant effects of physiological variables on SDs in the late phase after ischemia support the hypothesis that the impact of SDs may be modified by adjusting physiological variables.<\/jats:p>","DOI":"10.1177\/0271678x211039628","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T07:59:54Z","timestamp":1629791994000},"page":"121-135","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Physiological variables in association with spreading depolarizations in the late phase of ischemic stroke"],"prefix":"10.1177","volume":"42","author":[{"given":"Leonie","family":"Schumm","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Neurosurgery, Carl von Ossietzky Universit\u00e4t Oldenburg, Oldenburg, Germany"},{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coline L","family":"Lemale","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0970-1308","authenticated-orcid":false,"given":"Sebastian","family":"Major","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-649X","authenticated-orcid":false,"given":"Nils","family":"Hecht","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Nieminen-Kelh\u00e4","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Zdunczyk","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina M","family":"Kowoll","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Martus","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Institute for Clinical Epidemiology and Applied Biostatistics, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane M","family":"Thiel","sequence":"additional","affiliation":[{"name":"Biological Psychology, Department of Psychology, Carl von Ossietzky Universit\u00e4t Oldenburg, Oldenburg, Germany"},{"name":"Research Center Neurosensory Science, Carl von Ossietzky Universit\u00e4t Oldenburg, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-2828","authenticated-orcid":false,"given":"Jens P","family":"Dreier","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Woitzik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Carl von Ossietzky Universit\u00e4t Oldenburg, Oldenburg, Germany"},{"name":"Center for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"bibr1-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(78)90122-7"},{"key":"bibr2-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh545"},{"key":"bibr3-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1944.7.6.359"},{"key":"bibr4-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16657092"},{"key":"bibr5-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1947.10.6.409"},{"key":"bibr6-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2333"},{"key":"bibr7-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25147"},{"key":"bibr8-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.007"},{"key":"bibr9-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.11"},{"key":"bibr10-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21390"},{"key":"bibr11-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182886932"},{"key":"bibr12-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.09.027"},{"key":"bibr13-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004475"},{"key":"bibr14-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/nn1902"},{"key":"bibr15-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.17"},{"key":"bibr16-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412453340"},{"key":"bibr17-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.03.014"},{"key":"bibr18-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91062-1"},{"key":"bibr19-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.73"},{"key":"bibr20-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp102"},{"key":"bibr21-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu241"},{"key":"bibr22-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600252"},{"key":"bibr23-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl392"},{"key":"bibr24-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.191"},{"key":"bibr25-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16654495"},{"key":"bibr26-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199603000-00004"},{"key":"bibr27-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01769-2"},{"key":"bibr28-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-37-11602.2003"},{"key":"bibr29-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy102"},{"key":"bibr30-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1159\/000118039"},{"key":"bibr31-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1927"},{"key":"bibr32-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr303"},{"key":"bibr33-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006814"},{"key":"bibr34-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70243-5"},{"key":"bibr35-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh716"},{"key":"bibr36-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16651269"},{"key":"bibr37-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.0961"},{"key":"bibr38-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25963"},{"key":"bibr39-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16654496"},{"key":"bibr40-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17699629"},{"key":"bibr41-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.3171\/2009.8.FOCUS09148"},{"key":"bibr42-0271678X211039628","unstructured":"Council NR. Guide for the care and use of laboratory animals: eighth edition.  Washington, DC:  The National Academies Press; 2011, 246 p."},{"key":"bibr43-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20943823"},{"key":"bibr44-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200103000-00002"},{"key":"bibr45-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.653204"},{"key":"bibr46-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000113692.38574.57"},{"key":"bibr47-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1179\/1743132813Y.0000000214"},{"key":"bibr48-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20915801"},{"key":"bibr49-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)13112-8"},{"key":"bibr50-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2014"},{"key":"bibr51-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.40"},{"key":"bibr52-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.52"},{"key":"bibr53-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.35"},{"key":"bibr54-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.12.032"},{"key":"bibr55-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.04.004"},{"key":"bibr56-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.08.049"},{"key":"bibr57-0271678X211039628","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16689801"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X211039628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X211039628","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X211039628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:13:35Z","timestamp":1777493615000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X211039628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/0271678X211039628"],"URL":"https:\/\/doi.org\/10.1177\/0271678x211039628","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,24]]}}}