{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:58:50Z","timestamp":1789790330258,"version":"4.0.1"},"reference-count":69,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    Functional alterations after ischemic stroke have been described with Magnetic Resonance Imaging (MRI) and perfusion Positron Emission Tomography (PET), but no data on in vivo synaptic changes exist. Recently, imaging of synaptic density became available by targeting synaptic vesicle protein 2\u2009A, a protein ubiquitously expressed in all presynaptic nerve terminals. We hypothesized that in subacute ischemic stroke loss of synaptic density can be evaluated with\n                    <jats:sup>11<\/jats:sup>\n                    C-UCB-J PET in the ischemic tissue and that alterations in synaptic density can be present in brain regions beyond the ischemic core. We recruited ischemic stroke patients to undergo\n                    <jats:sup>11<\/jats:sup>\n                    C-UCB-J PET\/MR imaging 21\u2009\u00b1\u20098\u2009days after stroke onset to investigate regional\n                    <jats:sup>11<\/jats:sup>\n                    C-UCB-J SUVR (standardized uptake value ratio). There was a decrease (but residual signal) of\n                    <jats:sup>11<\/jats:sup>\n                    C-UCB-J SUVR within the lesion of 16 stroke patients compared to 40 healthy controls (ratio\n                    <jats:sub>lesion\/controls<\/jats:sub>\n                    \u2009=\u20090.67\u2009\u00b1\u20090.28, p\u2009=\u20090.00023). Moreover,\n                    <jats:sup>11<\/jats:sup>\n                    C-UCB-J SUVR was lower in the non-lesioned tissue of the affected hemisphere compared to the unaffected hemisphere (\u0394SUVR\u2009=\u2009\u22120.17, p\u2009=\u20090.0035). The contralesional cerebellar hemisphere showed a lower\n                    <jats:sup>11<\/jats:sup>\n                    C-UCB-J SUVR compared to the ipsilesional cerebellar hemisphere (\u0394SUVR\u2009=\u2009\u22120.14, p\u2009=\u20090.0048). In 8 out of 16 patients, the asymmetry index suggested crossed cerebellar diaschisis. Future research is required to longitudinally study these changes in synaptic density and their association with outcome.\n                  <\/jats:p>","DOI":"10.1177\/0271678x211047759","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T13:16:31Z","timestamp":1632316591000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Changes in synaptic density in the subacute phase after ischemic stroke: A\n                    <sup>11<\/sup>\n                    C-UCB-J PET\/MR study"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-5334","authenticated-orcid":false,"given":"Laura","family":"Michiels","sequence":"first","affiliation":[{"name":"Department of Neurosciences, KU Leuven, Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium"},{"name":"Department of Neurology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-7586","authenticated-orcid":false,"given":"Nathalie","family":"Mertens","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselot","family":"Thijs","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Radwan","sequence":"additional","affiliation":[{"name":"Translational MRI, KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-4680","authenticated-orcid":false,"given":"Stefan","family":"Sunaert","sequence":"additional","affiliation":[{"name":"Translational MRI, KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"},{"name":"Department of Radiology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium"},{"name":"Department of Geriatric Psychiatry, University Psychiatric Centre, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Verheyden","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Koole","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, KU Leuven, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"},{"name":"Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, KU Leuven, Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium"},{"name":"Department of Neurology, University Hospitals Leuven, Leuven, 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