{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:28:27Z","timestamp":1794274107218,"version":"4.9.0"},"reference-count":59,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    The serotonin 1B (5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    ) receptor has lately received considerable interest in relation to psychiatric and neurological diseases, partly due to findings based on quantification using Positron Emission Tomography (PET). Although the brainstem is an important structure in this regard, PET radioligand binding quantification in brainstem areas often shows poor reliability. This study aims to improve PET quantification of 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor binding in the brainstem.\n                  <\/jats:p>\n                  <jats:p>\n                    Volumes of interest (VOIs) were selected based on a 3D [\n                    <jats:sup>3<\/jats:sup>\n                    H]AZ10419369 Autoradiography brainstem model, which visualized 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor distribution in high resolution. Two previously developed VOI delineation methods were tested and compared to a conventional manual method. For a method based on template data, a [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 PET template was created by averaging parametric binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) images of 52 healthy subjects. VOIs were generated based on a predefined volume and BP\n                    <jats:sub>ND<\/jats:sub>\n                    thresholding and subsequently applied to test-retest [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 parametric BP\n                    <jats:sub>ND<\/jats:sub>\n                    images of 8 healthy subjects. For a method based on individual subject data, VOIs were generated directly on each individual parametric image.\n                  <\/jats:p>\n                  <jats:p>\n                    Both methods showed improved reliability compared to a conventional manual VOI. The VOIs created with [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 template data can be automatically applied to future PET studies measuring 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor binding in the brainstem.\n                  <\/jats:p>","DOI":"10.1177\/0271678x211049185","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T20:44:48Z","timestamp":1634157888000},"page":"630-641","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-8400","authenticated-orcid":false,"given":"Emma R","family":"Veldman","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Varrone","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Varn\u00e4s","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie M","family":"Svedberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"},{"name":"Department of Health Promotion Science, Sophiahemmet University, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Csel\u00e9nyi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"},{"name":"PET Science Centre, Personalized Medicine and Biosamples, R&D, AstraZeneca, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Tiger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Guly\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Halldin","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-3936","authenticated-orcid":false,"given":"Johan","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"bibr1-0271678X211049185","first-page":"904","volume":"39","author":"Rousset OG","year":"1998","journal-title":"J Nucl Med"},{"key":"bibr2-0271678X211049185","unstructured":"B\u00e9 MM, Chist\u00e9 V, Dulieu C, et\u00a0al.\n                      Table of radionuclides, comments on evaluations 5.\n                      LNHB Report. 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