{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:47:22Z","timestamp":1777794442936,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>The purpose of our study is to quantify the extent to which Virchow-Robin spaces (VRS) detected on in vivo MRI are reproducible by post-mortem MRI.<\/jats:p>\n                  <jats:p>Double Echo Steady State 3T MRIs were acquired post-mortem in 49 double- and 32 single-hemispheric formalin-fixed brain sections from 12 patients, who underwent conventional diagnostic 1.5 or 3T MRI in median 22 days prior to death (25% to 75%: 12 to 134 days). The overlap of in vivo and post-mortem VRS segmentations was determined accounting for potential confounding factors.<\/jats:p>\n                  <jats:p>The reproducibility of VRS found on in vivo MRI by post-mortem MRI, in the supratentorial white matter was in median 80% (25% to 75%: 60 to 100). A lower reproducibility was present in the basal ganglia, with a median of 47% (25% to 75%: 30 to 50).<\/jats:p>\n                  <jats:p>VRS segmentations were histologically confirmed in one double hemispheric section.<\/jats:p>\n                  <jats:p>Overall, the majority of VRS found on in vivo MRI was stable throughout death and formalin fixation, emphasizing the translational potential of post-mortem VRS studies.<\/jats:p>","DOI":"10.1177\/0271678x211067455","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T19:56:52Z","timestamp":1652903812000},"page":"1224-1235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Post-mortem correlates of Virchow-Robin spaces detected on\n                    <i>in vivo<\/i>\n                    MRI"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-1770","authenticated-orcid":false,"given":"Lukas","family":"Haider","sequence":"first","affiliation":[{"name":"NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London Institute of Neurology, London, UK"},{"name":"Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Hametner","sequence":"additional","affiliation":[{"name":"Clinical Institute of Neurology, Centre for Brain Research, Medical University of Vienna, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Endmayr","sequence":"additional","affiliation":[{"name":"Clinical Institute of Neurology, Centre for Brain Research, Medical University of Vienna, Wien, 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