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In studies with deep brain stimulation - DBS, when follow-on with functional magnetic resonance imaging and\/or PET-CT (Positron emission tomography\u2013computed tomography) is performed, it is observed an increase in the blood supply and glucose metabolism in this region, which is the anterior part of the limbic system. This same location has good experimental results also for the treatment of anorexia nervosa. The hypotheses suggest a greater activation of the reward system, a greater sense of well-being, and a consequent reduction in depressive symptoms, the objective of the treatment. Over the last 20 years, multicenter studies have shown symptomatic improvement in 50\u201360% of patients, and about a third even reach criteria for remission of the depressive disorder.<\/jats:p>","DOI":"10.1177\/0271678x221074279","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T07:47:18Z","timestamp":1642664838000},"page":"683-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Molecular basis and clinical perspectives of deep brain stimulation for major depressive disorder"],"prefix":"10.1177","volume":"42","author":[{"given":"Saulo Ara\u00fajo","family":"Teixeira","sequence":"first","affiliation":[{"name":"Hospital Geral de Fortaleza \u2013 HGF, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Lucas de Sousa","family":"Moreira","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal 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