{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:46:39Z","timestamp":1793025999027,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>\n                    [\n                    <jats:sup>18<\/jats:sup>\n                    F]MK-6240 is a second-generation tau PET-tracer to quantify neurofibrillary tangles in-vivo. However, individually variable levels of meningeal uptake induce spill-in-effects into the cortex, complicating [\n                    <jats:sup>18<\/jats:sup>\n                    F]MK-6240 PET quantification. Group SUVR differences between age-matched HC subgroups with varying extracerebral uptake (EC-low\/mixed\/high), and between aMCI and each HC subgroup were assessed without and with partial volume correction (PVC). Both M\u00fcller-Gartner (MG-)PVC and region-based voxelwise (RBV-)PVC, with the latter also correcting for extracerebral spill-in-effects, were implemented. Between HC groups, where no differences are to be expected, HC EC-high showed spill-in differences compared to HC EC-low when no PVC was applied while for MG-PVC, differences were reduced and, for RBV-PVC, no statistically significant differences were observed. Between aMCI and HC, cortical SUVR differences were statistically significant, both without and with PVC, but modulated by the varying meningeal uptake in HC subgroups when no PVC was applied. After applying PVC, correlations to clinical parameters improved and effect sizes between HC and aMCI increased, independent of the HC-subgroup. Therefore, appropriate PVC with correction for extracerebral spill-in-effects is recommended to minimize the impact of varying meningeal uptake on cortical differences between HC and aMCI.\n                  <\/jats:p>","DOI":"10.1177\/0271678x221076023","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T02:45:56Z","timestamp":1642819556000},"page":"1236-1246","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of meningeal uptake and partial volume correction techniques on [\n                    <sup>18<\/sup>\n                    F]MK-6240 binding in aMCI patients and healthy controls"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-7586","authenticated-orcid":false,"given":"Nathalie","family":"Mertens","sequence":"first","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, University Hospital and KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-5334","authenticated-orcid":false,"given":"Laura","family":"Michiels","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven \u2013 University of Leuven, Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium"},{"name":"Department of Neurology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greet","family":"Vanderlinden","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, University Hospital and KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven \u2013 University of Leuven, Leuven, Belgium"},{"name":"Old-Age Psychiatry, University Hospital and KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven \u2013 University of Leuven, Leuven, Belgium"},{"name":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium"},{"name":"Department of Neurology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, University Hospital and KU Leuven, Leuven, Belgium"},{"name":"Division of Nuclear Medicine, University Hospitals Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Koole","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging, University Hospital and KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"bibr1-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009818"},{"key":"bibr2-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0962-7"},{"key":"bibr3-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002892"},{"key":"bibr4-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0342-8"},{"key":"bibr5-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-019-01344-x"},{"key":"bibr6-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04496-0"},{"key":"bibr7-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.245423"},{"key":"bibr8-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.208215"},{"key":"bibr9-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.209650"},{"key":"bibr10-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0402-y"},{"key":"bibr11-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19887781"},{"key":"bibr12-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04419-z"},{"key":"bibr13-0271678X221076023","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-019-01367-w"},{"key":"bibr14-0271678X221076023","first-page":"1","author":"Kreisl 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