{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:31:14Z","timestamp":1789115474064,"version":"build-2803163510"},"reference-count":63,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    Post-stroke cognitive impairment is related to the effects of the acute stroke and pre-stroke brain health. We tested whether diffusion tensor imaging (DTI) can detect acute, global effects of stroke and predict post-stroke cognitive performance. Patients with stroke or TIA enrolled in a prospective cohort study were included if they had 1) at least one DTI acquisition at acute presentation, 24 hours, 5 days, or 30 days, and 2) follow-up testing with the telephone Montreal Cognitive Assessment (T-MoCA) at 30 and\/or 90 days. A whole brain, white-matter skeleton excluding the infarct was used to derive mean global DTI measures for mean diffusivity (MD), fractional anisotropy (FA), free water (FW), FW-corrected MD (MD\n                    <jats:sub>tissue<\/jats:sub>\n                    ), and FW-corrected FA (FA\n                    <jats:sub>tissue<\/jats:sub>\n                    ). In 74 patients with ischemic stroke or TIA, there was a transient 4.2% increase in mean global FW between acute presentation and 24 hours (p\u2009=\u20090.024) that returned to initial values by 30 days (p\u2009=\u20090.03). Each acute global DTI measure was associated with 30-day T-MoCA score (n\u2009=\u200961, p\u2009=\u20090.0011\u20130.0076). Acute global FW, MD, FA and FA\n                    <jats:sub>tissue<\/jats:sub>\n                    were also associated with 90-day T-MoCA (n\u2009=\u200956, p\u2009=\u20090.0034\u20130.049). Transient global FW elevation likely reflects stroke-related interstitial edema, whereas other global DTI measures are more representative of pre-stroke brain health.\n                  <\/jats:p>","DOI":"10.1177\/0271678x221101644","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T18:41:43Z","timestamp":1652899303000},"page":"1854-1866","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Global changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2703-7669","authenticated-orcid":false,"given":"Kyle C","family":"Kern","sequence":"first","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton B","family":"Wright","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-1815","authenticated-orcid":false,"given":"Richard","family":"Leigh","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA"},{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 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