{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:31:09Z","timestamp":1793053869878,"version":"4.5.0"},"reference-count":69,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    For the first time, labeling effects after oral intake of [1-13C]glucose are observed in the human brain with pure 1H detection at 9.4\u2009T. Spectral time series were acquired using a short-TE 1H MRS MC-semiLASER (Metabolite Cycling semi Localization by Adiabatic SElective Refocusing) sequence in two voxels of 5.4\u2009mL in the frontal cortex and the occipital lobe. High-quality time-courses of [4-13C]glutamate, [4-13C]glutamine, [3-13C]glutamate\u2009+\u2009glutamine, [2-13C] glutamate+glutamine and [3-13C]aspartate for individual volunteers and additionally, group-averaged time-courses of labeled and non-labeled brain glucose could be obtained. Using a one-compartment model, mean metabolic rates were calculated for each voxel position: The mean rate of the TCA-cycle (Vtca) value was determined to be 1.36 and 0.93\u2009\u03bcmol\u2009min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2009g\n                    <jats:sup>\u22121<\/jats:sup>\n                    , the mean rate of glutamine synthesis (Vgln) was calculated to be 0.23 and 0.45\u2009\u03bcmol\u2009min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2009g\n                    <jats:sup>\u22121<\/jats:sup>\n                    , the mean exchange rate between cytosolic amino acids and mitochondrial Krebs cycle intermediates (Vx) rate was found to be 0.57 and 1.21\u2009\u03bcmol\u2009min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2009g\n                    <jats:sup>\u22121<\/jats:sup>\n                    for the occipital lobe and the frontal cortex, respectively. These values were in agreement with previously reported data. Altogether, it can be shown that this most simple technique combining oral administration of [1-13C]Glc with pure 1H MRS acquisition is suitable to measure metabolic rates.\n                  <\/jats:p>","DOI":"10.1177\/0271678x221104540","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:11:12Z","timestamp":1653700272000},"page":"1890-1904","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Measurement of glucose metabolism in the occipital lobe and frontal cortex after oral administration of [1-13C]glucose at 9.4 T"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7847-1713","authenticated-orcid":false,"given":"Theresia","family":"Ziegs","sequence":"first","affiliation":[{"name":"High\u2010Field MR Center, Max Planck Institute for Biological Cybernetics, T\u00fcbingen, Germany"},{"name":"IMPRS for Cognitive and Systems Neuroscience, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-6291","authenticated-orcid":false,"given":"Johanna","family":"Dorst","sequence":"additional","affiliation":[{"name":"High\u2010Field MR Center, Max Planck Institute for Biological Cybernetics, T\u00fcbingen, Germany"},{"name":"IMPRS for Cognitive and Systems Neuroscience, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreen","family":"Ruhm","sequence":"additional","affiliation":[{"name":"High\u2010Field MR Center, Max Planck Institute for Biological Cybernetics, T\u00fcbingen, Germany"},{"name":"IMPRS for Cognitive and Systems Neuroscience, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Avdievitch","sequence":"additional","affiliation":[{"name":"High\u2010Field MR Center, Max Planck Institute for Biological Cybernetics, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Henning","sequence":"additional","affiliation":[{"name":"High\u2010Field MR Center, Max Planck Institute for Biological Cybernetics, T\u00fcbingen, Germany"},{"name":"Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"bibr1-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.679"},{"key":"bibr2-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10053"},{"key":"bibr3-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63041377.x"},{"key":"bibr4-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(02)00217-9"},{"key":"bibr5-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12479"},{"key":"bibr6-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1042\/bj2980121"},{"key":"bibr7-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb08271.x"},{"key":"bibr8-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.6.1633"},{"key":"bibr9-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9603"},{"key":"bibr10-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199911000-00002"},{"key":"bibr11-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27003"},{"key":"bibr12-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.847"},{"key":"bibr13-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.844"},{"key":"bibr14-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142131"},{"key":"bibr15-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1761"},{"key":"bibr16-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1772"},{"key":"bibr17-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4172"},{"key":"bibr18-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20129"},{"key":"bibr19-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.001"},{"key":"bibr20-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22160"},{"key":"bibr21-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25150"},{"key":"bibr22-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.07.010"},{"key":"bibr23-0271678X221104540","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28188"},{"key":"bibr24-0271678X221104540","unstructured":"Pfrommer A, Avdievich NI, Henning A. 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