{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:00:48Z","timestamp":1793714448780,"version":"4.6.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Accumulating evidence suggests asymmetrical responses of cerebral blood flow during large transient changes in mean arterial pressure. Specifically, the augmentation in cerebral blood flow is attenuated when mean arterial pressure acutely increases, compared with declines in cerebral blood flow when mean arterial pressure acutely decreases. However, common analytical tools to quantify dynamic cerebral autoregulation assume autoregulatory responses to be symmetric, which does not seem to be the case. Herein, we provide the rationale supporting the notion we need to consider the directional sensitivity of large and transient mean arterial pressure changes when characterizing dynamic cerebral autoregulation.<\/jats:p>","DOI":"10.1177\/0271678x221104868","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:28:41Z","timestamp":1653611321000},"page":"2351-2353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Point\/counterpoint: We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification"],"prefix":"10.1177","volume":"42","author":[{"given":"Lawrence","family":"Labrecque","sequence":"first","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Research Center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Smirl","sequence":"additional","affiliation":[{"name":"Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada"},{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada"},{"name":"Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada"},{"name":"Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chieh","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Surgery & Anesthesia, University of Otago, Wellington School of Medicine & Health Sciences, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6254-5044","authenticated-orcid":false,"given":"Patrice","family":"Brassard","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Research Center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"bibr1-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.152066"},{"key":"bibr2-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00790.2016"},{"key":"bibr3-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00269.2021"},{"key":"bibr4-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00653.2021"},{"key":"bibr5-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00010.2018"},{"key":"bibr6-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00332.2007"},{"key":"bibr7-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005293"},{"key":"bibr8-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.259747"},{"key":"bibr9-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/aa9086"},{"key":"bibr10-0271678X221104868","doi-asserted-by":"publisher","DOI":"10.1113\/EP090159"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X221104868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X221104868","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X221104868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:13:59Z","timestamp":1777493639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X221104868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1177\/0271678X221104868"],"URL":"https:\/\/doi.org\/10.1177\/0271678x221104868","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]}}}