{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:52:12Z","timestamp":1782456732169,"version":"3.54.5"},"reference-count":38,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Active conductive head cooling is a simple and non-invasive intervention that may slow infarct growth in ischemic stroke. We investigated the effect of active conductive head cooling on brain temperature using whole brain echo-planar spectroscopic imaging. A cooling cap (WElkins Temperature Regulation System, 2nd Gen) was used to administer cooling for 80 minutes to healthy volunteers and chronic stroke patients. Whole brain echo-planar spectroscopic imaging scans were obtained before and after cooling. Brain temperature was estimated using the Metabolite Imaging and Data Analysis System software package, which allows voxel-level temperature calculations using the chemical shift difference between metabolite (N-acetylaspartate, creatine, choline) and water resonances. Eleven participants (six healthy volunteers, five post-stroke) underwent 80\u2009\u00b1\u20095 minutes of cooling. The average temperature of the coolant was 1.3\u2009\u00b1\u20090.5\u00b0C below zero. Significant reductions in brain temperature (\u0394T\u2009=\u2009\u20130.9\u2009\u00b1\u20090.7\u00b0C, P\u2009=\u20090.002), and to a lesser extent, rectal temperature (\u0394T\u2009=\u2009\u20130.3\u2009\u00b1\u20090.1\u00b0C, P\u2009=\u20090.03) were observed. Exploratory analysis showed that the occipital lobes had the greatest reduction in temperature (\u0394T\u2009=\u2009\u20131.5\u2009\u00b1\u20091.2\u00b0C, P\u2009=\u20090.002). Regions of infarction had similar temperature reductions to the contralateral normal brain. Future research could investigate the feasibility of head cooling as a potential neuroprotective strategy in patients being considered for acute stroke therapies.<\/jats:p>","DOI":"10.1177\/0271678x221107988","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T03:05:04Z","timestamp":1655348704000},"page":"2058-2065","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Active conductive head cooling of normal and infarcted brain: A magnetic resonance spectroscopy imaging study"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3808-4428","authenticated-orcid":false,"given":"William K","family":"Diprose","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Department of Neurology, Auckland City Hospital, Auckland, New 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Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne C","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman","family":"Sheriff","sequence":"additional","affiliation":[{"name":"Department of Radiology, Miller School of Medicine, University of Miami, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Alan","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Department of 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