{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:23:43Z","timestamp":1778138623746,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    This study was aiming at investigating the extent of neuronal damage in cases of traumatic brain injury (TBI) with diffuse axonal injury (DAI) using\n                    <jats:sup>123<\/jats:sup>\n                    I-iomazenil(IMZ) SPECT and MRI. We compared the findings in 31 patients with TBI without any major focal brain lesions and 25 age-matched normal controls. Subjects underwent\n                    <jats:sup>123<\/jats:sup>\n                    I-IMZ SPECT and MRI, and also assessment by cognitive function tests. The partial volume effect of\n                    <jats:sup>123<\/jats:sup>\n                    I-IMZ SPECT was corrected using MRI. In the patients with TBI, decreased spatial concentration of\n                    <jats:sup>123<\/jats:sup>\n                    I-IMZ binding was detected in the medial frontal\/orbitofrontal cortex, posterior cingulate gyrus, cuneus, precuneus, and superior region of the cerebellum. ROC analysis of\n                    <jats:sup>123<\/jats:sup>\n                    I-IMZ SPECT for the detection of neuronal injury showed a high diagnostic ability of\n                    <jats:sup>123<\/jats:sup>\n                    I-IMZ binding density for TBI in these areas. The decreased\n                    <jats:sup>123<\/jats:sup>\n                    I-IMZ uptake density in the cuneus and precuneus was associated with cognitive decline after the injury. In the patients with TBI, brain atrophy was detected in the frontal lobe, anterior temporal and parietal cortex, corpus callosum, and posterior part of the cerebellum. Evaluation of the neuronal integrity by\n                    <jats:sup>123<\/jats:sup>\n                    I-IMZ SPECT and MRI provides important information for the diagnosis and pathological interpretation in cases of TBI with DAI.\n                  <\/jats:p>","DOI":"10.1177\/0271678x221113001","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:12:50Z","timestamp":1657181570000},"page":"2245-2254","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Impaired neuronal integrity in traumatic brain injury detected by\n                    <sup>123<\/sup>\n                    I-iomazenil single photon emission computed tomography and MRI"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-6772","authenticated-orcid":false,"given":"Hiroki","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoji","family":"Nakagawara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hachisuka","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hatazawa","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hokkaido University Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Suehiro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Iwate Medical University, Morioka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurology & Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Ishiai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Sapporo Medical University, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Saitama Rehabilitation Center, Ageo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Nariai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Shiga","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Hokkaido University, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurology & Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, 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