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A significant negative correlation between blood pressure, age and CBF was observed across the patient cohort. The lowest CBF values were recorded in the group of patients with hypertension that were prescribed with anti-hypertensive drugs, but uncontrolled on medication. These findings confirm that hypertension is associated with reduced cerebral perfusion and highlight the importance of blood pressure control for the benefit of maintaining brain blood flow.<\/jats:p>","DOI":"10.1177\/0271678x221124644","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:16:11Z","timestamp":1663114571000},"page":"2188-2190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Cerebral perfusion in untreated, controlled, and uncontrolled hypertension"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-0331","authenticated-orcid":false,"given":"Isabel N","family":"Christie","sequence":"first","affiliation":[{"name":"Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan","family":"Windsor","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-0307","authenticated-orcid":false,"given":"Henk JMM","family":"Mutsaerts","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Tillin","sequence":"additional","affiliation":[{"name":"MRC Unit for Lifelong Health & Ageing, Population Science & Experimental Medicine, Faculty of Population Health Sciences, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole H","family":"Sudre","sequence":"additional","affiliation":[{"name":"MRC Unit for Lifelong Health & Ageing, Population Science & Experimental Medicine, Faculty of Population Health Sciences, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5432-5271","authenticated-orcid":false,"given":"Alun D","family":"Hughes","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, Population Science & Experimental Medicine, Faculty of Population Health Sciences, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Golay","sequence":"additional","affiliation":[{"name":"Queen Square Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V","family":"Gourine","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S","family":"Hosford","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"bibr1-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313260"},{"key":"bibr2-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00430-6"},{"key":"bibr3-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002033"},{"key":"bibr4-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18255"},{"key":"bibr5-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00279"},{"key":"bibr6-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117031"},{"key":"bibr7-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309493"},{"key":"bibr8-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20966975"},{"key":"bibr9-0271678X221124644","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0074"}],"container-title":["Journal of Cerebral Blood Flow &amp; 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