{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:26:03Z","timestamp":1792189563488,"version":"4.4.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n                    The choroid plexus (ChP) comprises a collection of modified ependymal cells that play an important role in the production of brain cerebrospinal fluid (CSF), and ChP perfusion aberrations have been implicated in a range of cerebrovascular and neurodegenerative disorders. To provide an exemplar for the growing interest in ChP activity, we evaluated ChP perfusion and bulk CSF flow cross-sectionally across the healthy adult lifespan. Participants (n\u2009=\u200977; age range\u2009=\u200921\u201386 years) were scanned at 3T using T\n                    <jats:sub>1<\/jats:sub>\n                    -weighted, T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted-FLAIR, perfusion-weighted pCASL, and phase contrast MRI to calculate ChP anatomy, perfusion, and aqueductal CSF flow, respectively. Regression models were applied to evaluate aging effects on ChP volume and ChP perfusion in the lateral ventricles, as well as CSF flow. ChP volume (mean\u2009\u00b1\u2009std\u2009=\u20092.81\u2009\u00b1\u20091.1\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    ) increased (p\u2009&lt;\u20090.001), ChP perfusion (36.3\u2009\u00b1\u20098.6\u2009mL\/100\u2009g\/min) decreased (p\u2009=\u20090.0078), and ChP total blood flow (1.13\u2009\u00b1\u20090.34\u2009mL\/min) increased (p\u2009&lt;\u20090.001) with age. Cranial-to-caudal net CSF flow (0.245\u2009\u00b1\u20090.20\u2009mL\/min) decreased, absolute CSF flow (4.86\u2009\u00b1\u20092.96\u2009mL\/min) increased, and CSF regurgitant fraction (0.87\u2009\u00b1\u20090.126) increased with age (all: p\u2009&lt;\u20090.001). ChP perfusion was directly related to net cranial-to-caudal CSF flow through the aqueduct (p\u2009=\u20090.033). The implications of these findings are discussed in the context of the growing literature on CSF circulatory dysfunction in neurodegeneration and cerebrovascular disease.\n                  <\/jats:p>","DOI":"10.1177\/0271678x221129101","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T05:06:08Z","timestamp":1665032768000},"page":"269-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-5469","authenticated-orcid":false,"given":"Jarrod J","family":"Eisma","sequence":"first","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin D","family":"McKnight","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Hett","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Elenberger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel O","family":"Claassen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manus J","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"bibr1-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-11-10"},{"key":"bibr2-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.4103\/bc.BC_3_18"},{"key":"bibr3-0271678X221129101","first-page":"1","volume":"31","author":"Cushing H.","year":"1914","journal-title":"J Med Res"},{"key":"bibr4-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"bibr5-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19872563"},{"key":"bibr6-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00218-z"},{"key":"bibr7-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118270"},{"key":"bibr8-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21670"},{"key":"bibr9-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI45749.2020.9098443"},{"key":"bibr10-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.734992"},{"key":"bibr11-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4030"},{"key":"bibr12-0271678X221129101","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26181"},{"key":"bibr13-0271678X221129101","first-page":"R20","volume":"262","author":"Nilsson C","year":"1992","journal-title":"Am J Physiol"},{"key":"bibr14-0271678X221129101","unstructured":"Najafi A, Sartoretti TDJ, Binkert CA, et\u00a0al. 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