{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:01:00Z","timestamp":1793815260850,"version":"4.6.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    Post-stroke intra-infarct repair promotes peri-infarct neural reorganization leading to functional recovery. Herein, we examined the remodeling of extracellular matrix proteins (ECM) that constitute the intact basal membrane after permanent middle cerebral artery occlusion (pMCAO) in mice. Among ECM, collagen type IV remained localized on small vessel walls surrounding CD31-positive endothelial cells within infarct areas. Fibronectin was gradually deposited from peri-infarct areas to the ischemic core, in parallel with the accumulation of PDGFR\u03b2-positive cells. Cultured PDGFR\u03b2-positive pericytes produced fibronectin, which was enhanced by the treatment with PDGF-BB. Intra-infarct deposition of fibronectin was significantly attenuated in pericyte-deficient Pdgfrb\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice. Phagocytic activity of macrophages against myelin debris was significantly enhanced on fibronectin-coated dishes. In contrast, laminin \u03b12, produced by GFAP- and aquaporin 4-positive astrocytes, accumulated strongly in the boundary of peri-infarct areas. Pericyte-conditioned medium increased the expression of laminin \u03b12 in cultured astrocytes, partly through TGF\u03b21. Laminin \u03b12 increased the differentiation of oligodendrocyte precursor cells into oligodendrocytes and the expression of myelin-associated proteins. Peri-infarct deposition of laminin \u03b12 was significantly reduced in Pdgfrb\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice, with attenuated oligodendrogenesis in peri-infarct areas. Collectively, intra-infarct PDGFR\u03b2-positive cells may orchestrate post-stroke remodeling of key ECM that create optimal environments promoting clearance of myelin debris and peri-infarct oligodendrogenesis.\n                  <\/jats:p>","DOI":"10.1177\/0271678x221145092","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T03:50:35Z","timestamp":1670989835000},"page":"518-530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["PDGFR\n                    <b>\u03b2<\/b>\n                    -positive cell-mediated post-stroke remodeling of fibronectin and laminin\n                    <b>\u03b1<\/b>\n                    2 for tissue repair and functional recovery"],"prefix":"10.1177","volume":"43","author":[{"given":"Tomoya","family":"Shibahara","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 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