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First, brain volumes of hemodialysis patients (\u226455 years) were compared against age- and sex-matched healthy controls, and differences were revealed in bilateral insular cisterns width, maximum cerebral sulci width, Evans index, ventricular-brain ratio, frontal atrophy index, and temporal lobe ratio. Then, the patients were divided equally into \u201cno or mild\u201d or \u201csevere\u201d CA groups. Potential factors influencing CA were screened. Kt\/V (urea removal index) and hemoglobin levels negatively correlated with CA degree, and were used to establish a nomogram within randomly assigned training and validation patient groups. The areas under the receiver operating characteristic curves (AUROC) for training and validation groups were 0.703 and 0.744, respectively. When potassium and calcium were added to the nomogram, the AUROC for training\/validation group increased to 0.748\/0.806. The nomogram had optimal AUROC for training (0.759) and validation (0.804) groups when albumin was also included. Hemodialysis patients showed reduced anterior brain volumes and the nomogram established herein may have predictive value for developing CA.<\/jats:p>","DOI":"10.1177\/0271678x231151621","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:43:21Z","timestamp":1674013401000},"page":"882-892","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Dialysis adequacy and hemoglobin levels predict cerebral atrophy in maintenance-hemodialysis patients"],"prefix":"10.1177","volume":"43","author":[{"given":"Ming-Xuan","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Neurology and Psychiatry, Beijing Shijitan Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Institute of Brain Disorders, Capital Medical University, Beijing, 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