{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:50:37Z","timestamp":1777794637848,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n                    Transmembrane AMPA receptor regulatory protein \u03b3-8 (TARP \u03b3-8) mediates various AMPA receptor functions. Recently, [\n                    <jats:sup>11<\/jats:sup>\n                    C]TARP-2105 was developed as a PET ligand for TARP \u03b3-8 imaging. We performed a full kinetic analysis of [\n                    <jats:sup>11<\/jats:sup>\n                    C]TARP-2105 using PET with [\n                    <jats:sup>11<\/jats:sup>\n                    C]TARP-2105 for the first time. The distribution volume ( V\n                    <jats:sub>T<\/jats:sub>\n                    ), which is a macro parameter consisting of the K\n                    <jats:sub>1<\/jats:sub>\n                    \u2013 k\n                    <jats:sub>4<\/jats:sub>\n                    rate constants in the two-tissue compartment model analysis, exhibited the following rank order: hippocampus (1.4\u2009\u00b1\u20090.3)\u2009&gt;\u2009amygdala (1.0\u2009\u00b1\u20090.2)\u2009&gt;\u2009frontal cortex (0.9\u2009\u00b1\u20090.2)\u2009&gt;\u2009striatum (0.8\u2009\u00b1\u20090.2)\u2009\u226b cerebellum (0.5\u2009\u00b1\u20090.1)\u2009\u2248\u2009thalamus (0.5\u2009\u00b1\u20090.1)\u2009&gt;\u2009pons (0.4\u2009\u00b1\u20090.1\u2009mL\/cm\n                    <jats:sup>3<\/jats:sup>\n                    ). These heterogenous V\n                    <jats:sub>T<\/jats:sub>\n                    values corresponded with the order of biological distribution of TARP \u03b3-8 in the brain. To validate the reference tissue model, the binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) of [\n                    <jats:sup>11<\/jats:sup>\n                    C]TARP-2105 for TARP \u03b3-8 was estimated using general methods (SRTM, MRTM0, Logan reference model, and ratio method). These BP\n                    <jats:sub>ND<\/jats:sub>\n                    s based on reference models indicated excellent correlation (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009&gt;\u20090.9) to the indirect BP\n                    <jats:sub>ND<\/jats:sub>\n                    s based on 2TCM with moderate reproducibility (%variability\u2009\u2248\u200910). PET with [\n                    <jats:sup>11<\/jats:sup>\n                    C]TARP-2105 enabled noninvasive BP\n                    <jats:sub>ND<\/jats:sub>\n                    estimation and visual mapping of TARP \u03b3-8 in the living rat brain.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231152025","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T02:27:23Z","timestamp":1674095243000},"page":"893-904","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Small-animal PET study for noninvasive quantification of transmembrane AMPA receptor regulatory protein\n                    <b>\u03b3<\/b>\n                    -8 (TARP\n                    <b>\u03b3<\/b>\n                    -8) in the brain"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7773-3665","authenticated-orcid":false,"given":"Tomoteru","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuto","family":"Hiraishi","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsushi","family":"Kumata","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekatsu","family":"Wakizaka","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiding","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"},{"name":"SHI Accelerator Service Ltd., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"},{"name":"SHI Accelerator Service Ltd., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuki","family":"Nengaki","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"},{"name":"SHI Accelerator Service Ltd., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinlong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-6315","authenticated-orcid":false,"given":"Steven","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"bibr1-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.002451"},{"key":"bibr2-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10603"},{"key":"bibr3-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08165.x"},{"key":"bibr4-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1113\/JP276698"},{"key":"bibr5-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201812264"},{"key":"bibr6-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1113\/JP278701"},{"key":"bibr7-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.04.007"},{"key":"bibr8-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.044"},{"key":"bibr9-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8411"},{"key":"bibr10-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1038\/nature23479"},{"key":"bibr11-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1038\/nature18961"},{"key":"bibr12-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14639"},{"key":"bibr13-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14557"},{"key":"bibr14-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53485-9.00011-8"},{"key":"bibr15-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709000042"},{"key":"bibr16-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.263772"},{"key":"bibr17-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05081.x"},{"key":"bibr18-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00377"},{"key":"bibr19-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.231712"},{"key":"bibr20-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.243"},{"key":"bibr21-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8043(00)00392-4"},{"key":"bibr22-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.010"},{"key":"bibr23-0271678X231152025","first-page":"1836","volume":"36","author":"Keyes JW","year":"1995","journal-title":"J Nucl Med"},{"key":"bibr24-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.105908"},{"key":"bibr25-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"bibr26-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.130"},{"key":"bibr27-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.127"},{"key":"bibr28-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0066"},{"key":"bibr29-0271678X231152025","first-page":"513","volume":"37","author":"Ichise M","year":"1996","journal-title":"J Nucl Med"},{"key":"bibr30-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00008"},{"key":"bibr31-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.051292"},{"key":"bibr32-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000085441.37552.CA"},{"key":"bibr33-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212116"},{"key":"bibr34-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2005.08.009"},{"key":"bibr35-0271678X231152025","first-page":"4595","volume":"53","author":"Francois H","year":"1993","journal-title":"Cancer Res"},{"key":"bibr36-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600493"},{"key":"bibr37-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20716"},{"key":"bibr38-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2289-15.2016"},{"key":"bibr39-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2013.09.001"},{"key":"bibr40-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199809000-00003"},{"key":"bibr41-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-015-0993-3"},{"key":"bibr42-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150302"},{"key":"bibr43-0271678X231152025","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.06.002"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X231152025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X231152025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X231152025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:14:18Z","timestamp":1777493658000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X231152025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,18]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/0271678X231152025"],"URL":"https:\/\/doi.org\/10.1177\/0271678x231152025","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,18]]}}}