{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:55:11Z","timestamp":1787655311128,"version":"build-2736575974"},"reference-count":67,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    Cerebral blood flow (CBF) increases during hypoxia to counteract the reduction in arterial oxygen content. The onset of tissue hypoxemia coincides with the stabilization of hypoxia-inducible factor (HIF) and transcription of downstream HIF-mediated processes. It has yet to be determined, whether HIF down- or upregulation can modulate hypoxic vasodilation of the cerebral vasculature. Therefore, we examined whether: 1) CBF would increase with iron depletion (via chelation) and decrease with repletion (via iron infusion) at high-altitude, and 2) explore whether genotypic advantages of highlanders extend to HIF-mediated regulation of CBF. In a double-blinded and block-randomized design, CBF was assessed in 82 healthy participants (38 lowlanders, 20 Sherpas and 24 Andeans), before and after the infusion of either: iron(III)-hydroxide sucrose, desferrioxamine or saline. Across both lowlanders and highlanders, baseline iron levels contributed to the variability in cerebral hypoxic reactivity at high altitude (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.174, P\u2009&lt;\u20090.001). At 5,050\u2009m, CBF in lowlanders and Sherpa were unaltered by desferrioxamine or iron. At 4,300\u2009m, iron infusion led to 4\u2009\u00b1\u200910% reduction in CBF (main effect of time p\u2009=\u20090.043) in lowlanders and Andeans. Iron status may provide a novel, albeit subtle, influence on CBF that is potentially dependent on the severity and length-of-stay at high altitude.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231152734","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T04:38:14Z","timestamp":1678250294000},"page":"1166-1179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Manipulation of iron status on cerebral blood flow at high altitude in lowlanders and adapted highlanders"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-6195","authenticated-orcid":false,"given":"Alexander","family":"Patrician","sequence":"first","affiliation":[{"name":"Centre for Heart, Lung, & Vascular Health, School of Health and Exercise Sciences, University of British Columbia \u2013 Okanagan, Kelowna, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Willie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, & Vascular Health, School of Health and Exercise Sciences, University of British Columbia \u2013 Okanagan, Kelowna, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-0059","authenticated-orcid":false,"given":"Ryan L","family":"Hoiland","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, & Vascular Health, School of Health and Exercise Sciences, University of British Columbia \u2013 Okanagan, Kelowna, BC, Canada"},{"name":"Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada"},{"name":"Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada"},{"name":"International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gasho","sequence":"additional","affiliation":[{"name":"Pulmonary\/Critical Care Section, VA Loma Linda Healthcare System and Department of Medicine, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajan","family":"Subedi","sequence":"additional","affiliation":[{"name":"Pulmonary\/Critical Care Section, VA Loma Linda Healthcare System and Department of Medicine, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Anholm","sequence":"additional","affiliation":[{"name":"Pulmonary\/Critical Care Section, VA Loma Linda Healthcare System and Department of Medicine, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M","family":"Tymko","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, & Vascular Health, School of Health and Exercise Sciences, University of British Columbia \u2013 Okanagan, Kelowna, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N","family":"Ainslie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, & Vascular Health, School of Health and Exercise Sciences, University of British Columbia \u2013 Okanagan, Kelowna, BC, 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