{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:11:32Z","timestamp":1780362692703,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Nicotinic acetylcholine \u03b17 receptors (\u03b17 nAChRs) have a well-known modulator effect in neuroinflammation. Yet, the therapeutical effect of \u03b17 nAChRs activation after stroke has been scarcely evaluated to date. The role of \u03b17 nAChRs activation with PHA 568487 on inflammation after brain ischemia was assessed with positron emission tomography (PET) using [\n                    <jats:sup>18<\/jats:sup>\n                    F]DPA-714 and [\n                    <jats:sup>18<\/jats:sup>\n                    F]BR-351 radiotracers after transient middle cerebral artery occlusion (MCAO) in rats. The assessment of brain oedema, blood brain barrier (BBB) disruption and neurofunctional progression after treatment was evaluated with T\n                    <jats:sub>2<\/jats:sub>\n                    weighted and dynamic contrast-enhanced magnetic resonance imaging (T\n                    <jats:sub>2<\/jats:sub>\n                    W and DCE-MRI) and neurological evaluation. The activation of \u03b17 nAChRs resulted in a decrease of ischemic lesion, midline displacement and cell neurodegeneration from days 3 to 7 after ischemia. Besides, the treatment with PHA 568487 improved the neurofunctional outcome. Treated ischemic rats showed a significant [\n                    <jats:sup>18<\/jats:sup>\n                    F]DPA-714-PET uptake reduction at day 7 together with a decrease of activated microglia\/infiltrated macrophages. Likewise, the activation of \u03b17 receptors displayed an increase of [\n                    <jats:sup>18<\/jats:sup>\n                    F]BR-351-PET signal in ischemic cortical regions, which resulted from the overactivation of MMP-2. Finally, the treatment with PHA 568487 showed a protective effect on BBB disruption and blood brain vessel integrity after cerebral ischemia.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231161207","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T02:54:11Z","timestamp":1678762451000},"page":"1301-1316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic effect of\n                    <b>\u03b1<\/b>\n                    7 nicotinic receptor activation after ischemic stroke in rats"],"prefix":"10.1177","volume":"43","author":[{"given":"Laura","family":"Aguado","sequence":"first","affiliation":[{"name":"Achucarro Basque Center for Neuroscience, Leioa, Spain"},{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, 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