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This paper uses a multimodal NIRS-MRI method to quantify these parameters in rodent brain and, in so doing, provides novel information on the regulation of oxygen metabolism by stimulating with hypercapnia or variations in oxygenation. Under hypercapnia, although oxygenation, oxidation state, and CBF increased, there was no increase in CMRO\n                    <jats:sub>2<\/jats:sub>\n                    . Also, there was no correlation between CBF and CCO oxidation state. Conversely, changing oxygenation resulted in a strong correlation between the oxidation of CCO and CBF. This proves that the association between CBF and the redox state of CCO is not fixed and depends on the type of perturbation. Having a means to measure CBF and CCO oxidation state simultaneously will help understanding their contribution to intact neurovascular coupling and detecting abnormal cellular oxygen metabolism in many neurological disorders.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231165842","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T04:12:41Z","timestamp":1679544761000},"page":"1351-1364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The relationship between cytochrome c oxidase, CBF and CMRO\n                    <sub>2<\/sub>\n                    in mouse cortex: A NIRS-MRI study"],"prefix":"10.1177","volume":"43","author":[{"given":"Mada","family":"Hashem","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Radiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Alberta, Canada"},{"name":"Experimental Imaging Centre, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Alberta, Canada"},{"name":"Experimental Imaging Centre, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff F","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Alberta, Canada"},{"name":"Experimental Imaging Centre, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"bibr1-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2016.57.223"},{"key":"bibr2-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.047"},{"key":"bibr3-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"bibr4-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.228551"},{"key":"bibr5-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.017"},{"key":"bibr6-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.056"},{"key":"bibr7-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.06.008"},{"key":"bibr8-0271678X231165842","first-page":"1101","volume":"9","author":"Hoiland RL","year":"2011","journal-title":"Comprehensive Physiology"},{"key":"bibr9-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101995"},{"key":"bibr10-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.153"},{"key":"bibr11-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.42"},{"key":"bibr12-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116315"},{"key":"bibr13-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1007\/s00723-021-01345-y"},{"key":"bibr14-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.118935"},{"key":"bibr15-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.435532"},{"key":"bibr16-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101994"},{"key":"bibr17-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1945.143.1.53"},{"key":"bibr18-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20943823"},{"key":"bibr19-0271678X231165842","doi-asserted-by":"publisher","DOI":"10.1117\/12.469442"},{"key":"bibr20-0271678X231165842","unstructured":"Johnson TW.\n                      Measurement of brain oxygenation and metabolism in a mouse model of multiple sclerosis\n                      . 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