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Sixty-four healthy adults (18\u201385 years, N\u2009=\u200934 female) completed a visual stimulus evoked NVC assessment to a flashing checkerboard. NVC responses were measured in the posterior cerebral artery (PCAv) using transcranial Doppler ultrasound. A hierarchical multiple regression was used to determine the relationships between age, sex, and the age by sex interaction on NVC. There was a significant age by sex interaction for baseline (P\u2009=\u20090.001) and peak PCAv (P\u2009=\u20090.01), with a negative relationship with age in females (P\u2009&lt;\u20090.005), and no relationship in males (P\u2009\u2265\u20090.17). NVC responses as a percent increase from baseline showed a significant age by sex interaction (P\u2009=\u20090.014), with a positive relationship with age in females (P\u2009=\u20090.04) and no relationship in males (P\u2009=\u20090.17), even after adjusting for baseline PCAv. These data highlight important sex differences, with an association between age and NVC only apparent in females but not males, and thus a need to account for sex dependent effects of ageing when investigating cerebrovascular regulation.<\/jats:p>","DOI":"10.1177\/0271678x231167753","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T08:57:30Z","timestamp":1680685050000},"page":"1254-1266","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Sex modifies the relationship between age and neurovascular coupling in healthy adults"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-6840","authenticated-orcid":false,"given":"Jodie L","family":"Koep","sequence":"first","affiliation":[{"name":"Physiology and Ultrasound Laboratory in Science and Exercise, Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia"},{"name":"Children's Health and Exercise Research Centre, Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Bond","sequence":"additional","affiliation":[{"name":"Children's Health and Exercise Research Centre, Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R","family":"Barker","sequence":"additional","affiliation":[{"name":"Children's Health and Exercise Research Centre, Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-6506","authenticated-orcid":false,"given":"Stefanie L","family":"Ruediger","sequence":"additional","affiliation":[{"name":"Physiology and Ultrasound Laboratory in Science and Exercise, Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith K","family":"Pizzey","sequence":"additional","affiliation":[{"name":"Physiology and Ultrasound Laboratory in Science and Exercise, Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff S","family":"Coombes","sequence":"additional","affiliation":[{"name":"Physiology and Ultrasound Laboratory in Science and Exercise, Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom G","family":"Bailey","sequence":"additional","affiliation":[{"name":"Physiology and Ultrasound Laboratory in Science and Exercise, Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia"},{"name":"School of Nursing, Midwifery and Social Work, The University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"bibr1-0271678X231167753","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"bibr2-0271678X231167753","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.008"},{"key":"bibr3-0271678X231167753","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2091"},{"key":"bibr4-0271678X231167753","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0244-7"},{"key":"bibr5-0271678X231167753","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.162"},{"key":"bibr6-0271678X231167753","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170181"},{"key":"bibr7-0271678X231167753","first-page":"27","volume":"113","author":"Leenders KL","year":"1990","journal-title":"Normal Values and Effect of Age. 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