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Adult male mice were single- or pair-housed with an ovariectomized female mouse and then subjected to transient middle cerebral artery occlusion. Isolated mice were treated with the natriuretic peptide receptor A antagonist A71915 or anti-gamma-delta (\u03b3\u03b4) TCR monoclonal antibody, whereas pair-housed mice were treated with recombinant human atrial natriuretic peptide (rhANP). Subdiaphragmatic vagotomy (SDV) was performed 14\u2009days before single- or pair-housed conditions. We found that ISO significantly worsened brain and lung injuries relative to pair housing, which was partially mediated by elevated interleukin (IL)-17A levels and the migration of small intestine-derived inflammatory \u03b3\u03b4 T-cells into the brain and lung. However, rhANP treatment or SDV could ameliorate ISO-exacerbated post-stroke brain and lung damage by reducing IL-17A levels and inhibiting the migration of inflammatory \u03b3\u03b4 T-cells into the brain and lung. Our results suggest that rhANP mitigated ISO-induced exacerbation of SAP and ischemic cerebral injury by inhibiting small intestine-derived \u03b3\u03b4 T-cell migration into the lung and brain, which could be mediated by the subdiaphragmatic vagus nerve.<\/jats:p>","DOI":"10.1177\/0271678x231167946","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T09:06:44Z","timestamp":1680685604000},"page":"1267-1284","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal\n                    <b>\u03b3\u03b4<\/b>\n                    T-cell migration into the brain and lung"],"prefix":"10.1177","volume":"43","author":[{"given":"Bing","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. 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