{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:58:30Z","timestamp":1792699110144,"version":"4.5.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    The blood-brain barrier (BBB) breakdown has been suggested as an early marker for Alzheimer's disease (AD); yet the relationship between BBB breakdown and AD-specific biomarkers based on the amyloid\/tau\/neurodegeneration framework is not clear. This study investigated the relationship between BBB permeability, AD-specific biomarkers, and cognition in patients with cognitive impairment. In this prospective study, we enrolled 62 participants with mild cognitive impairment or dementia between January 2019 and October 2020. All participants were assessed through cognitive tests, amyloid positron emission tomography (PET), dynamic contrast-enhanced magnetic resonance imaging (MRI) for BBB permeability (K\n                    <jats:sub>trans<\/jats:sub>\n                    ), cerebrospinal fluid studies for A\u03b242\/40 ratio, phosphorylated-tau Thr181 protein (p-tau), total tau protein (t-tau), and structural MRI for neurodegeneration. In amyloid PET (+) group, higher cortical K\n                    <jats:sub>trans<\/jats:sub>\n                    was associated with lower A\u03b240 (r\u2009=\u2009\u22120.529 p\u2009=\u20090.003), higher A\u03b242\/40 ratio (r\u2009=\u20090.533, p\u2009=\u20090.003), lower p-tau (r\u2009=\u2009\u22120.452, p\u2009=\u20090.014) and lower hippocampal volume (r\u2009=\u2009\u22120.438, p\u2009=\u20090.017). In contrast, cortical K\n                    <jats:sub>trans<\/jats:sub>\n                    was positively related to t-tau level. (r\u2009=\u20090.489, p\u2009=\u20090.004) in amyloid PET (\u2212) group. Our results suggest that BBB permeability is related to AD-specific biomarkers, but the relationship can vary by the presence of A\u03b2 plaque accumulation.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231180035","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T04:54:15Z","timestamp":1686113655000},"page":"1813-1825","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Blood-brain barrier breakdown is linked to tau pathology and neuronal injury in a differential manner according to amyloid deposition"],"prefix":"10.1177","volume":"43","author":[{"given":"Yeonsil","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea"},{"name":"Research Institute of Medical Science, Konkuk University of Medicine, Seoul, Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Ja","family":"Kwon","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-7376","authenticated-orcid":false,"given":"Won-Jin","family":"Moon","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Science, Konkuk University of Medicine, Seoul, Republic of Korea"},{"name":"Department of Radiology, Konkuk University Medical Center, Seoul, Republic of 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