{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:06Z","timestamp":1787018766306,"version":"build-2736575974"},"reference-count":55,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    Evaluation of cerebrovascular reactivity (CVR) to hypo- and hypercapnia is a valuable test for the assessment of vasodilatory reserve. While hypercapnia-induced CVR testing is usually performed at normoxia, mild hyperoxia may increase tolerability of hypercapnia by reducing the ventilatory distress. However, the effects of mild hyperoxia on CVR was unknown. We therefore recruited 21 patients with a range of steno-occlusive diseases and 12 healthy participants who underwent a standardized 13-minute step plus ramp CVR test with a carbon dioxide gas challenge at the subject\u2019s resting end-tidal partial pressure of oxygen or at mild hyperoxia (PetO\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u2009150\u2009mmHg) depending on to which group they were assigned. In 11 patients, the second CVR test was at normoxia to examine test-retest differences. CVR was defined as % \u0394 Signal\/\u0394PetCO\n                    <jats:sub>2<\/jats:sub>\n                    . We found that there was no significant difference between CVR test results conducted at normoxia and at mild hyperoxia for participants in Groups 1 and 2 for the step and ramp portion. We also found no difference between test and retest CVR at normoxia for patients with cerebrovascular pathology (Group 3) for step and ramp portion. We concluded normoxic CVR is repeatable, and that mild hyperoxia does not affect CVR.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231197000","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T06:08:02Z","timestamp":1693030082000},"page":"2085-2095","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Determining the effects of elevated partial pressure of oxygen on hypercapnia-induced cerebrovascular reactivity"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-751X","authenticated-orcid":false,"given":"Ece Su","family":"Sayin","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Duffin","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Poublanc","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lashmikumar","family":"Venkatraghavan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David John","family":"Mikulis","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Arnold","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Sobczyk","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, 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