{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:05Z","timestamp":1787018765341,"version":"build-2736575974"},"reference-count":60,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    Hyperglycemia has been linked to worsening outcomes after subarachnoid hemorrhage (SAH). Nevertheless, the mechanisms involved in the pathogenesis of SAH have been scarcely evaluated so far. The role of hyperglycemia was assessed in an experimental model of SAH by T\n                    <jats:sub>2<\/jats:sub>\n                    weighted, dynamic contrast-enhanced magnetic resonance imaging (T\n                    <jats:sub>2<\/jats:sub>\n                    W and DCE-MRI), [\n                    <jats:sup>18<\/jats:sup>\n                    F]BR-351 PET imaging and immunohistochemistry. Measures included the volume of bleeding, the extent of cerebral infarction and brain edema, blood brain barrier disruption (BBBd), neutrophil infiltration and matrix metalloprotease (MMP) activation. The neurofunctional outcome, neurodegeneration and myelinization were also investigated. The induction of hyperglycemia increased mortality, the size of the ischemic lesion, brain edema, neurodegeneration and worsened neurological outcome during the first 3\u2009days after SAH in rats. In addition, these results show for the first time the exacerbating effect of hyperglycemia on in vivo MMP activation, Intercellular Adhesion Molecule 1 (ICAM-1) expression and neutrophil infiltration together with increased BBBd, bleeding volume and fibrinogen accumulation at days 1 and 3 after SAH. Notably, these data provide valuable insight into the detrimental effect of hyperglycemia on early BBB damage mediated by neutrophil infiltration and MMP activation that could explain the worse prognosis in SAH.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231197946","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T11:08:12Z","timestamp":1695208092000},"page":"726-741","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Multimodal imaging of the role of hyperglycemia following experimental subarachnoid hemorrhage"],"prefix":"10.1177","volume":"44","author":[{"given":"Ana","family":"Joya","sequence":"first","affiliation":[{"name":"Achucarro Basque Center for Neuroscience, Leioa, Spain"},{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Plaza-Garc\u00eda","sequence":"additional","affiliation":[{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Padro","sequence":"additional","affiliation":[{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Aguado","sequence":"additional","affiliation":[{"name":"Achucarro Basque Center for Neuroscience, Leioa, Spain"},{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyre","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Achucarro Basque Center for Neuroscience, Leioa, Spain"},{"name":"Neurovascular Group, Biocruces Health Research Institute, Barakaldo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maider","family":"Garbizu","sequence":"additional","affiliation":[{"name":"Achucarro Basque Center for Neuroscience, Leioa, Spain"},{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"G\u00f3mez-Vallejo","sequence":"additional","affiliation":[{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Laredo","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Comprehensive Stroke Center, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unai","family":"Coss\u00edo","sequence":"additional","affiliation":[{"name":"CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Torn\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Neurosurgery Department, Hospital Clinic of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-6390","authenticated-orcid":false,"given":"Sergio","family":"Amaro","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Comprehensive Stroke Center, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-1880","authenticated-orcid":false,"given":"Anna M","family":"Planas","sequence":"additional","affiliation":[{"name":"Area of Neurosciences. 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