{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:52:46Z","timestamp":1777794766751,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    Cerebral Amyloid Angiopathy (CAA) is characterized by cerebrovascular amyloid-\u03b2 accumulation leading to hallmark cortical MRI markers, such as vascular reactivity, but white matter is also affected. By studying the relationship in different disease stages of Dutch-type CAA (D-CAA), we tested the relation between vascular reactivity and microstructural white matter integrity loss. In a cross-sectional study in D-CAA, 3\u2009T MRI was performed with Blood-Oxygen-Level-Dependent (BOLD) fMRI upon visual activation to assess vascular reactivity and diffusion tensor imaging to assess microstructural white matter integrity through Peak Width of Skeletonized Mean Diffusivity (PSMD). We assessed the relationship between BOLD parameters \u2013 amplitude, time-to-peak (TTP), and time-to-baseline (TTB) \u2013 and PSMD, with linear and quadratic regression modeling. In total, 25 participants were included (15\/10 pre-symptomatic\/symptomatic; mean age 36\/59\u2009y). A lowered BOLD amplitude (unstandardized \u03b2\u2009=\u20090.64, 95%CI [0.10, 1.18], p\u2009=\u20090.02, Adjusted R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.48), was quadratically associated with increased PSMD levels. A delayed BOLD response, with prolonged TTP (\u03b2\u2009=\u20098.34\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    , 95%CI [1.84\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    , 1.48\u2009\u00d7\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    ], p\u2009=\u20090.02, Adj. R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.25) and TTB (\u03b2\u2009=\u20096.57\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    , 95%CI [1.92\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    , 1.12\u2009\u00d7\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    ], p\u2009=\u20090.008, Adj. R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.29), was linearly associated with increased PSMD. In D-CAA subjects, predominantly in the symptomatic stage, impaired cerebrovascular reactivity is related to microstructural white matter integrity loss. Future longitudinal studies are needed to investigate whether this relation is causal.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231200425","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:54:34Z","timestamp":1694699674000},"page":"2144-2155","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Microstructural white matter integrity in relation to vascular reactivity in Dutch-type hereditary cerebral amyloid angiopathy"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-0997","authenticated-orcid":false,"given":"Manon R","family":"Schipper","sequence":"first","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Vlegels","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-9379","authenticated-orcid":false,"given":"Thijs W","family":"van Harten","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg","family":"Rasing","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma A","family":"Koemans","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Voigt","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto de","family":"Luca","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-6853","authenticated-orcid":false,"given":"Kanishk","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis S","family":"van Etten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik W","family":"van Zwet","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela M","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-8959","authenticated-orcid":false,"given":"Matthias JP","family":"van Osch","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne AA","family":"van Walderveen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke JH","family":"Wermer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Neurology, University Medical Center Groningen, Groningen, The 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