{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:35:41Z","timestamp":1794036941041,"version":"4.8.0"},"reference-count":96,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    High-intensity interval training (HIIE) may present unique challenges to the cerebrovascular system in individuals post-stroke. We hypothesized lower middle cerebral artery blood velocity (MCAv) in individuals post-stroke: 1) during 10 minutes of HIIE, 2) immediately following HIIE, and 3) 30 minutes after HIIE, compared to age- and sex-matched controls (CON). We used a recumbent stepper submaximal exercise test to determine workloads for high-intensity and active recovery. Our low volume HIIE protocol consisted of 1-minute intervals for 10 minutes. During HIIE, we measured MCAv, mean arterial pressure (MAP), heart rate (HR), and end tidal carbon dioxide (P\n                    <jats:sub>ET<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    ). We assessed carotid-femoral pulse wave velocity as a measure of arterial stiffness. Fifty participants completed the study (25 post-stroke, 76% ischemic, 32% moderate disability). Individuals post-stroke had lower MCAv during HIIE compared to CON (p\u2009=\u20090.03), which remained 30 minutes after HIIE. Individuals post-stroke had greater arterial stiffness (p\u2009=\u20090.01) which was moderately associated with a smaller MCAv responsiveness during HIIE (r\u2009=\u2009\u22120.44). No differences were found for MAP, HR, and P\n                    <jats:sub>ET<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    . This study suggests individuals post-stroke had a lower MCAv during HIIE compared to their peers, which remained during recovery up to 30 minutes. Arterial stiffness may contribute to the lower cerebrovascular responsiveness post-stroke.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231201472","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:55:32Z","timestamp":1694699732000},"page":"627-640","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke"],"prefix":"10.1177","volume":"44","author":[{"given":"Alicen A","family":"Whitaker","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Medical College of Wisconsin, Milwaukee, WI, USA"},{"name":"Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 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