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Vascular endothelial growth factor-A (VEGF-A) is an important modulator of vascular health and VEGF-A promotes the brain\u2019s ability to recover after more severe forms of brain injury; however, the role of VEGF-A in mTBI remains poorly understood. Bevacizumab (BEV) is a monoclonal antibody that binds to VEGF-A and neutralises its actions. To better understand the role of VEGF-A in mTBI recovery, this study examined how BEV treatment affected outcomes in rats given a mTBI. Adult Sprague-Dawley rats were assigned to sham-injury\u2009+\u2009vehicle treatment (VEH), sham-injury\u2009+\u2009BEV treatment, mTBI\u2009+\u2009VEH treatment, mTBI\u2009+\u2009BEV treatment groups. Treatment was administered intracerebroventricularly via a cannula beginning at the time of injury and continuing until the end of the study. Rats underwent behavioral testing after injury and were euthanized on day 11. In both females and males, BEV had a negative impact on cognitive function. mTBI and BEV treatment increased the expression of inflammatory markers in females. In males, BEV treatment altered markers related to hypoxia and vascular health. These novel findings of sex-specific responses to BEV and mTBI provide important insights into the role of VEGF-A in mTBI.<\/jats:p>","DOI":"10.1177\/0271678x231212377","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T06:43:39Z","timestamp":1699339419000},"page":"542-555","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment with the vascular endothelial growth factor-A antibody, bevacizumab, has sex-specific effects in a rat model of mild traumatic brain injury"],"prefix":"10.1177","volume":"44","author":[{"given":"Mujun","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara L","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical 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