{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:35:54Z","timestamp":1784180154062,"version":"3.55.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    Existing methods for voxelwise transient dopamine (DA) release detection rely on explicit kinetic modeling of the [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride PET time activity curve, which at the voxel level is typically confounded by noise, leading to poor performance for detection of low-amplitude DA release-induced signals. Here we present a novel data-driven, task-informed method\u2014referred to as Residual Space Detection (RSD)\u2014that transforms PET time activity curves to a residual space where DA release-induced perturbations can be isolated and processed. Using simulations, we demonstrate that this method significantly increases detection performance compared to existing kinetic model-based methods for low-magnitude DA release (simulated +100% peak increase in basal DA concentration). In addition, results from nine healthy controls injected with a single bolus of [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride performing a finger tapping motor task are shown as proof-of-concept. The ability to detect relatively low magnitudes of dopamine release in the human brain using a single bolus injection, while achieving higher statistical power than previous methods, may additionally enable more complex analyses of neurotransmitter systems. Moreover, RSD is readily generalizable to multiple tasks performed during a single PET scan, further extending the capabilities of task-based single-bolus protocols.\n                  <\/jats:p>","DOI":"10.1177\/0271678x231214823","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:14:33Z","timestamp":1700180073000},"page":"757-771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel voxelwise residual analysis of [\n                    <sup>11<\/sup>\n                    C]raclopride PET data improves detection of low-amplitude dopamine release"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6258-8450","authenticated-orcid":false,"given":"Connor WJ","family":"Bevington","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-8446","authenticated-orcid":false,"given":"Jordan U","family":"Hanania","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ferraresso","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Chieh (Kevin)","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada"},{"name":"Pacific Parkinson\u2019s Research Centre, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pavel","sequence":"additional","affiliation":[{"name":"Pacific Parkinson\u2019s Research Centre, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongning","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Jon","family":"Stoessl","sequence":"additional","affiliation":[{"name":"Pacific Parkinson\u2019s Research Centre, University of British Columbia, Vancouver, Canada"},{"name":"Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7862-5711","authenticated-orcid":false,"given":"Vesna","family":"Sossi","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, University of British Columbia, Vancouver, 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