{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:42:28Z","timestamp":1791474148602,"version":"4.3.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Perinatal hypoxic-ischaemic encephalopathy (HIE) is the leading cause of irreversible brain damage resulting in serious neurological dysfunction among neonates. We evaluated the feasibility of positron emission tomography (PET) methodology with\n                    <jats:sup>15<\/jats:sup>\n                    O-labelled gases without intravenous or tracheal cannulation for assessing temporal changes in cerebral blood flow (\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">CBF<\/jats:italic>\n                    <\/jats:bold>\n                    ) and cerebral metabolic rate for oxygen (\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">\n                        CMRO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    ) in a neonatal HIE rat model. Sequential PET scans with spontaneous inhalation of\n                    <jats:sup>15<\/jats:sup>\n                    O-gases mixed with isoflurane were performed over 14\u2009days after the hypoxic-ischaemic insult in HIE pups and age-matched controls.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">CBF<\/jats:italic>\n                    <\/jats:bold>\n                    and\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">\n                        CMRO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    in the injured hemispheres of HIE pups remarkably decreased 2\u2009days after the insult, gradually recovering over 14\u2009days in line with their increase found in healthy controls according to their natural maturation process. The magnitude of hemispheric tissue loss histologically measured after the last PET scan was significantly correlated with the decreases in\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">CBF<\/jats:italic>\n                    <\/jats:bold>\n                    and\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">\n                        CMRO\n                        <jats:sub>2.<\/jats:sub>\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    This fully non-invasive imaging strategy may be useful for monitoring damage progression in neonatal HIE and for evaluating potential therapeutic outcomes.\n                  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